动脉粥样硬化是冠心病、脑梗死等心脑血管疾病的共同病理基础，而表观遗传修饰异常在动脉粥样硬化的发生、发展中起着关键作用。表观遗传修饰具有可逆性，其可成为药物干预的潜在靶点。姜黄素可通过影响组蛋白乙酰化修饰、调控DNA甲基化、调控微小RNA干预动脉粥样硬化。总结了姜黄素通过调控表观遗传修饰干预抗动脉粥样硬化的研究进展，为姜黄素作为表观遗传调控剂防治动脉粥样硬化提供新思路。

Atherosclerosis is the common pathological basis of cardiovascular and cerebrovascular diseases such as coronary heart disease and cerebral infarction, and epigenetic modification abnormalities play a key role in the occurrence and development of atherosclerosis. Epigenetic modification is reversible, which can be a potential target of drug intervention. Curcumin can interfere with atherosclerosis by influencing histone acetylation, regulating DNA methylation, and regulating microRNA. This article summarized the research progress of curcumin intervention in anti-atherosclerosis by regulating epigenetic modification, and provided a new idea for curcumin as an epigenetic regulator to prevent and treat atherosclerosis.

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湖南省自然科学基金区域联合基金资助项目（2025JJ70208）