多囊卵巢综合征是一类在女性群体中高发的生殖激素紊乱、代谢异常证候群，常伴有多种代谢异常，如胰岛素抵抗、肥胖和雄激素过多症。大豆异黄酮是一种含有12种组分且能发挥类雌激素作用的多酚结构混合物，属于大豆的次生代谢产物之一，又被称为“植物雌激素”，其主要成分为染料木素、大豆苷元。大豆异黄酮可通过改善胰岛素敏感性、调节脂质代谢、抗炎作用、抗氧化应激作用、双向调节肠道菌群发挥治疗多囊卵巢综合征的作用。总结了大豆异黄酮治疗多囊卵巢综合征的药理作用研究进展，为大豆异黄酮临床新疗法的开发提供参考。

Polycystic ovary syndrome is a common reproductive endocrine disorder and metabolic abnormality in women, often accompanied by conditions such as insulin resistance, obesity, and hyperandrogenism. Soy isoflavones, a mixture of polyphenolic compounds containing 12 components with estrogen-like effects, are secondary metabolites of soybeans and are also known as "phytoestrogens," primarily composed of genistein and daidzein. Soy isoflavones can treat polycystic ovary syndrome by improving insulin sensitivity, regulating lipid metabolism, anti-inflammatory effects, antioxidant stress response, and bidirectionally modulating gut microbiota. This article summarizes the pharmacological research progress of soy isoflavones in treating PCOS, providing a reference for the development of new clinical therapies involving soy isoflavones.

R287.4

国家自然科学基金面上项目（82374509，82174422）；黑龙江省自然科学基金资助项目（LH2023H062）；龙江科技英才春雁支持计划项目（2022CYCX0026）