目的 探讨地榆槐角丸联合聚乙二醇4000散治疗湿热证便秘的临床疗效。方法 选取2022年6月—2025年6月冕宁县人民医院就诊的湿热证便秘患者100例作为研究对象，采用随机数字表法分为对照组和治疗组，各50例。对照组给予聚乙二醇4000散，每次10 g，每日2次。治疗组在对照组治疗基础上加服地榆槐角丸，每次5 g，每日2次，温开水送服。两组疗程均为4周。观察两组的临床疗效，比较两组中医证候积分、便秘症状评估量表（PAC-SYM）评分、肠道黏膜屏障功能指标和血清炎症因子水平。结果 治疗后，治疗组总有效率为94.00%，显著高于对照组的80.00%（P＜0.05）。治疗后，两组PAC-SYM评分及中医证候评分均较同组治疗前显著降低（P＜0.05）；治疗后，治疗组PAC-SYM评分及中医证候评分均低于对照组（P＜0.05）。治疗后，两组D-乳酸（D-LA）及内毒素（LPS）水平均较同组治疗前显著下降（P＜0.05）；治疗后，治疗组D-LA及LPS水平低于对照组（P＜0.05）。经治疗后，两组血清白细胞介素-6（IL-6）及肿瘤坏死因子-α（TNF-α）水平均显著下降（P＜0.05）；治疗后，治疗组血清IL-6、TNF-α水低于对照组（P＜0.05）。结论 地榆槐角丸联合聚乙二醇4000散治疗湿热证便秘疗效确切，有助于减轻炎症反应，调节肠道黏膜屏障功能，从而改善便秘症状。

Objective To explore the clinical efficacy of Diyu Huaijiao Pills combined with Macrogol 4000 Powder in treatment of constipation of damp-heat syndrome. Methods A total of 100 patients with constipation of damp-heat syndrome who visited Mianning People’s Hospital from June 2022 to June 2025 were selected as the research subjects. They were randomly divided into control group and treatment group, with 50 cases in each group. The control group was given Macrogol 4000 Powder, 10 g each time, twice daily. The treatment group was additionally given Diyu Huaijiao Pills, 5 g each time, twice daily, taken with warm water. The treatment course for both groups was 4 weeks. The clinical efficacy of two groups was observed, and the TCM syndrome scores, constipation symptom assessment scale (PAC-SYM) scores, intestinal mucosal barrier function indicators, and serum inflammatory factor levels of two groups were compared. Results After treatment, the total effective rate of the treatment group was 94.00%, significantly higher than that of the control group (80.00%) (P < 0.05). After treatment, the PAC-SYM scores and TCM syndrome scores of both groups were significantly lower than those before treatment in same group (P< 0.05). After treatment, the PAC-SYM scores and TCM syndrome scores of treatment group were lower than those of control group (P < 0.05). After treatment, the D-LA and LPS levels of both groups were significantly lower than those before treatment in same group (P < 0.05). After treatment, the D-LA and LPS levels of treatment group were lower than those of control group (P < 0.05). After treatment, the serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels of both groups significantly decreased (P < 0.05). After treatment, the serum IL-6 and TNF-α levels of treatment group were lower than those of control group (P < 0.05). Conclusion The combination of Diyu Huaijiao Pills and Macrogol 4000 Powder has a definite therapeutic effect in treatment of constipation of damp-heat syndrome, and can reduce inflammatory responses and regulate the intestinal mucosal barrier function, thereby improving the symptoms of constipation.

R975