认知功能障碍是一类以记忆衰退、执行功能下降为核心特征的神经退行性疾病。胰高血糖素样肽-1（GLP-1）受体激动剂可通过直接神经保护作用、抑制神经炎症和氧化应激、改善胰岛素抵抗、调节脑–肠轴改善认知功能障碍。利拉鲁肽、艾塞那肽在临床前研究、临床研究中展现出改善认知功能障碍的潜力。总结了GLP-1受体激动剂改善认知功能障碍的研究进展，为其在认知功能障碍防治中的转化应用提供参考。

Cognitive dysfunction is a type of neurodegenerative disease characterized by memory decline and decreased executive function. Glucagon like peptide-1 (GLP-1) receptor agonists can improve cognitive impairment through direct neuroprotection, inhibition of neuroinflammation and oxidative stress, improvement of insulin resistance, and regulation of the brain gut axis. Liraglutide and exenatide have shown potential in improving cognitive impairment in preclinical and clinical studies. This article summarizes the research progress of GLP-1 receptor agonists in improving cognitive dysfunction, providing reference for their translational application in the prevention and treatment of cognitive dysfunction.

R977

中国人民解放军联勤保障部队优质专科建设基金资助项目