肺部疾病是一类累及气道、肺实质、肺血管的疾病统称，涵盖病毒性肺炎、支气管哮喘、急性肺损伤、肺纤维化、肺癌等多种类型，其治疗药物普遍存在耐药性、不良反应大或疗效局限等问题。栀子苷可通过抗病毒、抗炎、抗氧化应激、抗细胞凋亡、抗肺纤维化、抗肺部肿瘤发挥肺部保护作用，用于治疗肺部疾病。总结了栀子苷治疗肺部疾病的药理作用研究进展，为栀子苷的基础研究和药物开发提供参考。

Pulmonary diseases are a collective term for conditions affecting the airways, lung parenchyma, and pulmonary vasculature, encompassing various types such as viral pneumonia, bronchial asthma, acute lung injury, pulmonary fibrosis, and lung cancer. The therapeutic drugs for these conditions often face challenges like drug resistance, significant side effects, or limited efficacy. Gardenoside can exert pulmonary-protective effects by antiviral effect, anti-inflammatory effect, antioxidant stress, anti-apoptosis, anti-pulmonary fibrosis, anti-lung tumor to be suitable for treating pulmonary diseases. This article summarizes the pharmacological research progress on gardenoside in treating pulmonary diseases, providing a reference for its fundamental research and drug development.

R286.4