结直肠癌是全球高发的消化道恶性肿瘤，单药治疗疗效有限，且易诱发耐药性、不良反应较大。槲皮素从抑制肿瘤细胞增殖、抑制肿瘤细胞侵袭和迁移、诱导细胞死亡、减轻炎症反应、破坏氧化还原稳态、抑制肿瘤血管生成、逆转肿瘤化疗耐药性、协同增效作用多个维度防治结直肠癌。总结了槲皮素防治结直肠癌的药理作用研究进展，为结直肠癌的药物防治研究提供参考。

Colorectal cancer is a highly prevalent malignant tumor of the digestive tract worldwide, with limited efficacy of drug therapy, easy to induce drug resistance, and significant adverse reactions. Quercetin can prevent and treat colorectal cancer from multiple dimensions, including inhibiting tumor cell proliferation, inhibiting tumor cell invasion and migration, inducing cell death, reducing inflammatory response, disrupting redox homeostasis, inhibiting tumor angiogenesis, reversing tumor chemotherapy resistance, and synergistic effects. This article summarizes the pharmacological research progress of quercetin in prevention and treatment of colorectal cancer, providing reference for drug prevention and treatment research of colorectal cancer.

R286.7

如皋市指导性科技攻关计划（社会发展）项目[SRGS (24)047]