神经病理性疼痛是指由躯体感觉系统的损伤或疾病所导致的慢性疼痛，临床常用的治疗药物往往存在嗜睡、头晕、成瘾性等不良反应。氧化苦参碱是苦参中主要活性成分，可通过减轻氧化应激损伤、抑制神经炎症反应、调节神经递质稳态、抑制痛觉信号通路活化多维度发挥抗神经病理性疼痛作用。总结了氧化苦参碱治疗神经病理性疼痛的药理作用研究进展，为氧化苦参碱的基础研究和临床转化提供参考。

Neuropathic pain is a chronic pain caused by damage or illness of the somatosensory system, and commonly used therapeutic drugs in clinical practice often have adverse reactions such as drowsiness, dizziness, and addiction. Oxymatrine is the main active ingredient in Sophorae Flavescentis Radix, which can exert multidimensional anti-neuropathic pain effects by reducing oxidative stress damage, inhibiting neuroinflammatory reactions, regulating neurotransmitter homeostasis, and inhibiting the activation of pain signaling pathways. This article summarizes the pharmacological research progress of oxymatrine in treatment of neuropathic pain, providing reference for the basic research and clinical translation of oxymatrine.

R286.1

重庆市卫生健康委医学科研项目（2024WSJK100）