肥胖是一种高发病率的多因素疾病，可诱发心血管疾病、糖尿病、代谢相关脂肪性肝病、肿瘤等一系列严重并发症。吴茱萸中的主要成分之一吴茱萸碱具有多种药理活性，可通过调节脂肪代谢、调节能量代谢、调节肠道菌群、调节内分泌系统、抗炎、抗氧化干预肥胖发生、发展的多个病理生理环节，显示出潜在的抗肥胖临床应用前景。总结了吴茱萸碱治疗肥胖的药理作用研究进展，旨在为肥胖的药物治疗提供新的思路和方法。

Obesity is a multifactorial disease with high incidence rate, which can induce a series of serious complications, such as cardiovascular disease, diabetes, metabolic fatty liver disease, tumor, etc. As one of the main components in Evodiae Fructus, evodiamine has various pharmacological activities. Evodiamine can intervene in multiple pathophysiological processes of obesity occurrence and development by regulating fat metabolism, energy metabolism, gut microbiota, endocrine system, anti-inflammatory and antioxidant effects, demonstrating potential clinical application prospects for anti-obesity. This article summarizes the research progress on pharmacological effects of evodiamine in treatment of obesity, to provide new ideas and methods for drug treatment of obesity.

R286.7

辽宁省大学生创新创业训练计划项目（X202510159010）