糖尿病是一种由胰岛素分泌不足或胰岛素抵抗引起血糖水平升高的慢性全身性代谢疾病，但降糖药物普遍存在较多的不良反应。淫羊藿苷是从淫羊藿中提取的黄酮醇苷类化合物，可通过改善胰岛素抵抗、保护胰岛β细胞功能、抗炎作用、减轻线粒体功能障碍和氧化应激等药理作用治疗糖尿病及其并发症糖尿病心肌病、糖尿病肾病、糖尿病视网膜病变、糖尿病性骨质疏松症、糖尿病伤口延迟愈合等。总结淫羊藿苷治疗糖尿病及其并发症的药理作用研究进展，旨在为药物研发和临床应用提供参考。

Diabetes is a chronic systemic metabolic disease caused by insufficient insulin secretion or insulin resistance. Icarin is a flavonol glycoside compound extracted from Epimedii Folium. Icariin can treat diabetes and its complications, such as diabetes cardiomyopathy, diabetes nephropathy, diabetes retinopathy, diabetes osteoporosis, and diabetes wound delayed healing, etc. by improving insulin resistance, protecting the function of pancreatic islet β cells, anti-inflammatory effect, reducing mitochondrial dysfunction and oxidative stress. This article summarized the pharmacological effects of icariin in treatment of diabetes and its complications, in order to provide a reference for drug development and clinical application.

R286.7

甘肃省自然科学基金项目（25JRRA425）；中央高校基本科研业务费项（31920240058）