血管衰老作为机体衰老的核心表现，已成为多种心脑血管疾病的共同病理基础。近年来“肠道–血管轴”概念逐步完善，肠道菌群失衡及其代谢产物紊乱可诱发血管损伤、加速血管老化。中药多组分、多靶点的系统调节优势可通过双向调节肠道菌群结构、调节菌群代谢产物、修复肠道屏障功能、调控代谢物直接作用于血管等多途径干预血管衰老。围绕肠道–血管轴作用机制，综述了中药调节肠道菌群干预血管衰老的研究进展，为血管衰老的防治提供参考。

Vascular aging, serving as a core manifestation of systemic aging, has become a common pathological basis for various cardiovascular and cerebrovascular diseases. In recent years, the concept of the "gut-vascular axis" has gradually been refined, revealing that imbalances in gut microbiota and their metabolite dysregulation can induce vascular damage and accelerate vascular aging. The systematic regulatory advantages of traditional Chinese medicine, characterized by multiple components and targets, can intervene in vascular aging through bidirectional modulation of gut microbiota structure, regulation of microbial metabolites, restoration of intestinal barrier function, and direct action on the vascular system via metabolite pathways. This article reviews the research progress on Chinese herbal medicine modulates gut microbiota to intervene in vascular aging, providing references for the prevention and treatment of vascular aging.

R286.7

慢性非传染性疾病相关国家科技重大专项（2024ZD0539100）；深圳市医学研究专项资金项目（C2406001）