目的 观察鸦胆子油乳注射液联合SOX方案（替吉奥联合奥沙利铂）治疗晚期结肠癌的临床效果。方法 选取2023年1月—2024年1月南通市肿瘤医院收治的102例中晚期结肠癌患者为研究对象，依据不同治疗方案将患者分为对照组（50例）和治疗组（52例）。对照组接受SOX化疗方案，第1天静脉滴注注射用奥沙利铂（130 mg/m²）＋5%葡萄糖溶液250 mL混合液，滴注时间2 h，1次/d；第1～14天早晚餐后口服替吉奥胶囊40～60 mg/次，2次/d，连续服药14 d后停药7 d。治疗组在对照组治疗的基础上第1～5天静脉滴注鸦胆子油乳注射液30 mL＋氯化钠注射液250 mL混合液，滴注时间为2 h，1次/d。以21 d为1个治疗周期，两组连续治疗6个周期。比较两组患者的临床疗效、血清肿瘤标志物、毒副反应、生存率。结果 相较于对照组，治疗组的临床控制率更高（P＜0.05）。治疗后，两组血清癌胚抗原（CEA）、糖类抗原199（CA199）、糖类抗原72-4（CA72-4）水平均显著降低（P＜0.05）；相较于对照组治疗后，治疗组血清CEA、CA199、CA72-4水平均更低（P＜0.05）。治疗期间，治疗组消化道反应发生率低于对照组（P＜0.05）。随访1年，治疗组无病生存期、总生存期均长于对照组（P＜0.05）。结论 鸦胆子油乳注射液联合SOX化疗方案治疗中晚期结肠癌能够有效提升临床疗效，降低患者肿瘤恶性程度，抑制肿瘤血管生成，延长生存时间。

Objective To observe the effect of Yadanzi Oil Emulsion Injection combined with SOX chemotherapy in treatment of advanced colon cancer. Methods A total of 102 patients with advanced colon cancer admitted to Nantong Cancer Hospital from January 2023 to January 2024 were selected as the study subjects. Patients were divided into control group (50 cases) and treatment group (52 cases) according to different treatment plans. The control group received the SOX chemotherapy regimen. On the first day, a mixture of Oxaliplatin for injection (130 mg/m²) and 5% glucose solution (250 mL) was intravenously dripped for 2 h, once daily. From the first to 14th day, after breakfast and dinner, Tegafur, Gimeracil and Oteracil Potassium Capsules were orally administered after breakfast and dinner at 40 — 60 mg/time, twice daily, for 14 consecutive days before stopping for 7 d. The treatment group received a mixture of 30 mL Yadanzi Oil Emulsion Injection and 250 mL sodium chloride injection on the basis of the control group from the 1st to the 5th day, via intravenous drip for 2 h, once daily. The treatment cycle was 21 days, and two groups received 6 consecutive treatment cycles. The clinical efficacy, serum tumor markers, toxic side effects, and survival rate between two groups of patients were compared. Results The clinical control rate of the treatment group was higher than that of the control group (P < 0.05). After treatment, the serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA199), and carbohydrate antigen 72-4 (CA72-4) in two groups were significantly reduced (P < 0.05). After treatment, the serum levels of CEA, CA199, and CA72-4 in the treatment group were lower than those in the control group (P < 0.05). During the treatment period, the incidence of gastrointestinal reactions in the treatment group was lower than that in the control group (P < 0.05). After a one-year follow-up, the disease-free survival and overall survival of the treatment group were longer than those of the control group (P < 0.05). Conclusion The combination of Yadanzi Oil Emulsion Injection and SOX chemotherapy regimen can effectively improve the clinical effect of advanced colon cancer, reduce the malignancy of the patient's tumor, inhibit tumor angiogenesis, and prolong survival time.

R979.1

南通市卫生健康委员会科研课题（MS2023056）；南通大学临床医学专项科研基金项目（2023JQ007）