目的 评估脑梗死在阿司匹林片和硫酸氢氯吡格雷片基础上联合大活络胶囊治疗的临床效果。方法 选择2023年5月—2025年6月中国人民解放军联勤保障部队第九〇四医院收治的105例脑梗死患者为研究对象，按照随机数字表法将患者分为对照组（52例）和治疗组（53例）。对照组第1天口服阿司匹林片4片/次，第2～21天调整为2片/次，1次/d；第1天口服硫酸氢氯吡格雷片4片/次，第2～21 d调整为1片/次，1次/d。治疗组在对照组基础上口服大活络胶囊，4粒/次，3次/d，治疗21 d。比较两组临床疗效、神经功能、血清炎症因子和神经因子。结果 治疗后，治疗组的总有效率84.91%高于对照组的69.23%（P＜0.05）。治疗后，两组美国国立卫生研究院卒中量表（NIHSS）评分显著降低（P＜0.05），且治疗组的NIHSS评分低于对照组（P＜0.05）。治疗后，两组血清白细胞介素-6（IL-6）、超敏C反应蛋白（hs-CRP）水平均显著降低（P＜0.05），且治疗组的血清IL-6、hs-CRP水平低于对照组（P＜0.05）。治疗后，两组血清神经营养因子（BDNF）、神经生长因子（NGF）水平均显著升高（P＜0.05），且治疗组血清BDNF、NGF水平高于对照组（P＜0.05）。结论 大活络胶囊联合阿司匹林片和硫酸氢氯吡格雷片治疗脑梗死可提高临床疗效，促进神经功能恢复，降低炎症因子水平，改善神经因子。

Objective To evaluate the clinical efficacy of combining Aspirin Tablets and Clopidogrel Bisulfate Tablets with Dahuoluo Capsules in treatment of cerebral infarction. Methods 105 Patients with cerebral infarction admitted to 904th Hospital of the Joint Logistics Support Force of the People’s Liberation Army from May 2023 to June 2025 were selected as the research subjects. The patients were divided into control group (52 cases) and treatment group (53 cases) using a random number table method. The control group took Aspirin Tablets orally 4 tablets of on the first day, adjusted to 2 tablets per time from the second to the 21st day, once daily. On the first day, they took Clopidogrel Bisulfate Tablets orally 4 tablets, adjusted to 1 tablet per time from the second to the 21st day, once daily. The treatment group took Dahuoluo Capsules orally on the basis of the control group, 4 capsules per time, 3 times daily, for 21 days. The clinical efficacy, neurological function, serum inflammatory factors, and nerve factors of two groups were compared. Results After treatment, the total effective rate of the treatment group was 84.91%, which was higher than 69.23% of the control group (P < 0.05). After treatment, the National Institutes of Health Stroke Scale (NIHSS) scores of two groups significantly decreased (P < 0.05), and the NIHSS score of the treatment group was lower than that of the control group (P < 0.05). After treatment, the serum levels of interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) in two groups were significantly reduced (P < 0.05), and the serum levels of IL-6 and hs-CRP in the treatment group were lower than those in the control group (P < 0.05). After treatment, the serum levels of neurotrophic factor (BDNF) and nerve growth factor (NGF) significantly increased in two groups (P < 0.05), and the serum levels of BDNF and NGF in the treatment group were higher than those in the control group (P < 0.05). Conclusion The combination of Dahuoluo Capsules with Aspirin Tablets and Clopidogrel Bisulfate Tablets can improve clinical efficacy in treatment of cerebral infarction, promote neurological function recovery, reduce inflammatory cytokine levels, and improve neurological factors.

R971

无锡市卫生健康委科研项目（Z202217）