高血压作为一种常见的慢性疾病，在全球范围内的发病率和死亡率逐年升高。近年来，针对高血压治疗的新型药物开发取得了显著进展，包括经典作用机制药物组合、作用于肾素–血管紧张素–醛固酮系统（RAAS）的药物、作用于利钠肽系统的药物、内皮素受体拮抗剂。总结了新型高血压治疗药物的研究进展，为高血压的临床用药提供依据。

Hypertension, as a common chronic disease, has a year-on-year increase in both incidence and mortality rates worldwide. In recent years, significant progress has been made in the development of novel pharmacological therapies for hypertension, including combinations of classic mechanism-of-action drugs, medications targeting the renin-angiotensin-aldosterone system (RAAS), drugs acting on the natriuretic peptide system, and endothelin receptor antagonists. This article summarizes the research progress of novel pharmacological therapies for hypertension, providing a basis for clinical medication use in hypertension.