炎症性肠病是一组病因尚未完全阐明、以肠道慢性非特异性炎症为核心特征的消化系统疑难疾病，然而疾病易复发、疗效个体差异大、长期药物使用可能导致耐受性或系统性不良反应。柚皮素可降低氧化损伤，降低炎症损伤，降低肠道黏膜细胞凋亡，降低结肠纤维化，改善肠道屏障功能，调控肠道菌群，纠正血液高凝状态，发挥防治炎症性肠病的作用。综述了柚皮素治疗炎症性肠病的药理作用研究进展，为柚皮素的临床运用提供循证支持。

Inflammatory bowel disease is a difficult digestive system disease characterized by chronic non-specific inflammation of the intestine, with an unclear etiology. However, the disease is prone to recurrence, individual efficacy varies greatly, and long-term drug use may lead to tolerance or systemic adverse reactions. Naringin can reduce oxidative damage, inflammatory damage, intestinal mucosal cell apoptosis, and colon fibrosis, improve intestinal barrier function, regulate intestinal microbiota, correct blood hypercoagulability, and play a role in preventing and treating inflammatory bowel disease. This article reviews the pharmacological research progress of naringin in treatment of inflammatory bowel disease, providing evidence-based support for its clinical application.

枣庄市科技创项新工程（科技发展计划）项目（2024NS49）