多囊卵巢综合征是一种病因未明、临床表现多样的女性生殖内分泌疾病，其临床特征为卵巢多囊样改变、排卵功能障碍和高雄激素血症。目前多囊卵巢综合征的一线治疗方案是生活干预，辅以对症治疗的药物。丹参酮、芍药苷、穿心莲内酯等萜类成分能够通过调节核因子-κB、磷脂酰肌醇3-激酶/蛋白激酶B、促分裂原活化蛋白激酶、AMP依赖的蛋白激酶、Janus激酶/信号转导与转录激活因子等多条信号通路发挥调节激素水平，改善胰岛素抵抗的作用，达到治疗多囊卵巢综合征的目的。总结了中药萜类成分治疗多囊卵巢综合征的信号通路研究进展，以期为临床用药提供依据。

Polycystic ovary syndrome (PCOS) is a female reproductive endocrine disorder with unknown etiology and diverse clinical manifestations, characterized by ovarian polycystic changes, ovulatory dysfunction, and hyperandrogenism. The current first-line treatment for PCOS involves lifestyle interventions supplemented with symptomatic medication. Terpenoid components such as tanshinone, paeoniflorin, and andrographolide can regulate hormone levels and improve insulin resistance by modulating multiple signaling pathways, including nuclear factor-κB, phosphoinositide 3-kinase/protein kinase B, mitogen-activated protein kinase, AMP-dependent protein kinase, and Janus kinase/signal transducer and activator of transcription. This article summarizes the research progress on the signaling pathways of terpenoid compounds in treating PCOS, aiming to provide a basis for clinical medication.

国家自然科学基金资助项目（8217150735，8237152556）；黑龙江省自然科学基金资助项目（LH2023H062）；龙江科技英才春雁支持计划项目（2022CYCX0026）