目的 分析临沧市人民医院2018年12月—2025年12月急诊创伤外科创伤部位感染病原菌分布及耐药性，为临床合理预防及治疗提供参考。方法 搜集2018年12月—2025年12月临沧市人民医院急诊创伤外科送检的创伤部位的微生物标本，对其病原菌分布及耐药性进行统计分析。结果 共检出病原菌552株，标本以伤口分泌物为主，共检出449株（占81.4%）。病原菌以革兰阴性菌为主，共386株（占69.9%），常见的是大肠埃希菌、铜绿假单胞菌、阴沟肠杆菌和嗜麦芽窄食单胞菌；革兰阳性菌共166株（占30.1%），以金黄色葡萄球菌和粪肠球菌为主。金黄色葡萄球菌中对甲氧西林耐药的菌株检出率为20.8%，对青霉素耐药率为94.4%，粪肠球菌对所监测的抗菌药物的敏感性较好，均未检出对万古霉素和利奈唑胺耐药的菌株。大肠埃希菌中产超广谱β-内酰胺酶（ESBL）检出率为54.2%，阴沟肠杆菌对所监测的抗菌药物的敏感性较好。铜绿假单胞菌对绝大多数抗铜绿假单胞菌药物的敏感性较好；嗜麦芽窄食单胞菌对左氧氟沙星的耐药率为59.1%，对其他所监测的抗菌药物较敏感。结论 临沧市人民医院急诊创伤外科送检的创伤部位的微生物标本检出的病原菌以革兰阴性菌为主。病原菌对临床常用抗菌药物的耐药性各不相同，及时送检微生物标本，便于掌握病原学分布特点及耐药情况，为临床合理用药提供重要依据。

Objective To analyze the distribution and drug resistance of pathogenic bacteria causing trauma site infections in the department of emergency trauma surgery at The People's Hospital of Lincang from December 2018 to December 2025,and to provide reference for rational clinical prevention and treatment. Methods Microbiological specimens from traumatic sites were collected from the department of emergency trauma surgery at Lincang City People's Hospital from December 2018 to December 2025, and the detection and drug resistance rate of pathogenic bacteria were analyzed statistically. Results A total of 552 pathogenic bacteria were detected, of which 449 strains (81.4%) were wound secretions. Gram-negative bacteria were the main pathogens, with 386 strains (69.9%), and the most common were Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae and Stenotrophomonas maltophilia. Gram-positive bacteria accounted for 166 strains (30.1%), Staphylococcus aureus and Enterococcus faecalis were the most common. The detection rate of methicillin-resistant strains among Staphylococcus aureus was 20.8%, and the resistance rate to penicillin was 94.4%. Enterococcus faecalis showed better sensitivity to the monitored antibacterial drugs. And no strains resistant to vancomycin and linezolid were detected in either of the two. The detection rate of ESBL in Escherichia coli was 54.2%.Enterobacter cloacae showed better sensitivity to the monitored antibacterial drugs. Pseudomonas aeruginosa shows relatively good sensitivity to most anti-pseudomonal agents. The resistance rate of Stenotrophomonas maltophilia to levofloxacin was 59.1%, while it was relatively sensitive to the other monitored antibacterial drugs. Conclusion Gram-negative bacteria were the main pathogens detected in the microbial samples of the causing trauma site infections in the department of emergency trauma surgery at The People's Hospital of Lincang. The resistance of pathogenic bacteria to commonly used antibiotics in clinic is different. Timely submission of microbial specimens is necessary to facilitate the understanding of the distribution characteristics of pathogens and their drug resistance, providing an important basis for rational clinical drug use.

临沧市科技创新团队项目（202204AC100002-TD04）；临沧市“兴临人才”青年科技人才专项（LCXLRC2024B-04）；临沧市人民医院2025年医院科技计划项目（2025-30）