目的 探讨复方甘菊利多卡因凝胶联合氯己定治疗种植体周围炎的临床疗效。方法 回顾分析选取2020年11月—2025年12月唐山职业技术学院附属医院收治的100例种植体周围炎患者为研究对象，根据临床实际治疗方案将患者分为对照组和治疗组，每组各50例。对照组患者给予复方氯己定含漱液，早晚刷牙后含漱，10～20 mL/次，2～3次/d。治疗组在对照组治疗基础上给予复方甘菊利多卡因凝胶，每次取适量凝胶涂于患处，3次/d。两组连续用药2周。观察两组疗效情况，比较两组牙周相关指标、种植体牙周疼痛程度、患者龈沟液氧化应激因子和血清炎性因子。结果 治疗后，治疗组总有效率（96.00%）显著高于对照组（82.00%，P＜0.05）。治疗后，两组的菌斑指数（PLI）评分、龈沟出血指数（SBI）评分、探诊深度（PD）、视觉模拟疼痛（VAS）评分均较同组治疗前显著降低（P＜0.05）；治疗后，与对照组对比，治疗组PLI评分、SBI评分、PD、VAS评分均更低（P＜0.05）。治疗后，两组丙二醛（MDA）、一氧化氮（NO）水平与同组治疗前显著降低，而超氧化歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）显著升高（P＜0.05）；治疗后，与对照组对比，治疗组MDA、NO水平均降低，且SOD、GSH-Px水平均升高（P＜0.05）。治疗后，两组血清白细胞介素-1β（IL-1β）、干扰素调节因子4（IRF4）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平均较同组治疗前显著降低（P＜0.05）；治疗后，与对照组对比，治疗组IL-1β、IRF4、IL-6、TNF-α水平均降低（P＜0.05）。结论 复方甘菊利多卡因凝胶联合氯己定治疗种植体周围炎疗效较好，可协同抗炎与抗氧化作用，阻断种植体周围组织的破坏进程，同时改善PLI、SBI和PD等关键牙周临床指标，从而实现更全面的治疗效果。

Objective To explore the clinical efficacy of Compound Chamomile and Lidocaine Hydrochloride Gel combined with chlorhexidine in treatment of peri implant inflammation. Methods A retrospective analysis was conducted on 100 patients with peri implant inflammation admitted to the Affiliated Hospital of Tangshan Vocational and Technical College from November 2020 to December 2025. The patients were divided into control group and treatment group based on actual clinical treatment plans, with 50 patients in each group. Patients in control group were given Compound Gargle Solution Chlorhexidine Giuconatie, they were instructed to gargle after brushing teeth in morning and evening. The dosage was 10 — 20 mL per time, and they were required to do this 2 — 3 times daily. Patients in treatment group were given Compound Chamomile and Lidocaine Hydrochloride Gel in addition to treatment of control group. A suitable amount of gel was applied to the affected area each time, and this was done 3 times daily. Both groups continued the treatment for 2 weeks. The therapeutic effects of two groups were observed, and the periodontal-related indicators, the degree of implant periodontal pain, the oxidative stress factors in gingival crevicular fluid, and the inflammatory factors in serum of patients were compared between two groups. Results After treatment, the total effective rate of the treatment group (96.00%) was significantly higher than that of the control group (82.00%, P < 0.05). After treatment, the plaque index (PLI) score, gingival sulcus bleeding index (SBI) score, probing depth (PD), and visual analogue scale pain (VAS) score of both groups were significantly lower than those before treatment in the same group (P < 0.05). After treatment, compared with control group, the PLI score, SBI score, PD, and VAS score of treatment group were all lower (P < 0.05). After treatment, the levels of malondialdehyde (MDA) and nitric oxide (NO) in both groups were significantly lower than those before treatment in the same group, but superoxide dismutase (SOD) and glutathione peroxidase (GP-x) were significantly increased (P < 0.05). After treatment, compared with control group, the MDA and NO levels of treatment group were both lower, and the SOD and GP-x levels were both higher (P < 0.05). After treatment, the levels of serum interleukin-1β (IL-1β), interferon regulatory factor 4 (IRF4), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in both groups were significantly lower than those before treatment in the same group (P < 0.05). After treatment, compared with control group, the IL-1β, IRF4, IL-6, and TNF-α levels of treatment group were all lower (P < 0.05). Conclusion Compound Chamomile and Lidocaine Hydrochloride Gel combined with chlorhexidine has a better therapeutic effect in treating peri implant inflammation, and can synergistically exert anti-inflammatory and antioxidant effects, inhibit the destruction process of the surrounding tissues of the implant, and simultaneously improve key periodontal clinical indicators such as PLI, SBI and PD, thereby achieving a more comprehensive therapeutic effect.

河北省医学科学研究课题计划（20241455）