目的 探讨龙掌口含液联合甲硝唑治疗慢性牙龈炎的临床疗效。方法 选择2024年1月—2025年8月辽宁省健康产业集团阜新矿总医院收治的122例慢性牙龈炎患者作为研究对象，采用简单随机法将入组患者均等划分为对照组与治疗组，每组各61例。对照组患者饭后含服甲硝唑口颊片1片/次，3次/d，临睡前加用1片。治疗组在对照组基础上联合应用龙掌口含液漱口，10 mL/次，每次含漱2 min吐去，4次/d。两组患者连续治疗2周。观察两组患者的临床疗效，比较治疗前后的牙周指标[牙周探诊深度（PD）、龈沟出血指数（SBI）、菌斑指数（PLI）、牙龈指数（GI）]、龈沟液炎症因子[白细胞介素（IL）-1β、IL-6、IL-17和肿瘤坏死因子（TNF）-α]。结果 治疗组患者的总有效率为95.08%，明显优于对照组的83.61%（P＜0.05）。治疗后，两组患者的牙周指标PD、SBI、PLI、GI均较基线水平明显下降（P＜0.05），同时治疗组的上述牙周指标均显著低于对照组（P＜0.05）。治疗后，两组患者的龈沟液炎症因子IL-1β、IL-6、IL-17、TNF-α水平均较基线水平明显下降（P＜0.05），同时治疗组的各炎症因子均显著低于对照组（P＜0.05）。结论 龙掌口含液联合甲硝唑能够有效治疗慢性牙龈炎，改善牙周指标，抑制龈沟液炎症反应。

Objective To investigate the clinical efficacy and safety of Longzhang Oral Liquid combined with metronidazole in treatment of chronic gingivitis. Methods A total of 122 patients with chronic gingivitis in Liaoning Health Industry Group Fuxin Mining General Hospital from January 2024 to August 2025 were selected as the study subjects. They were equally divided into a control group and a treatment group by simple randomization, with 61 cases in each group. Patients in the control group received Metronidazole Buccal Tablets after meals (1 tablet/time, 3 times daily), plus 1 tablet at bedtime. On the basis of the control group, patients in the treatment group additionally used Longzhang Oral Liquid for gargling (10 mL/time, gargle for 2 minutes then spit out, 4 times daily). Both groups were treated continuously for 2 weeks. Clinical efficacy was observed, and periodontal indicators [probing depth (PD), sulcus bleeding index (SBI), plaque index (PLI), gingival index (GI)] as well as inflammatory cytokines in gingival crevicular fluid [interleukin-1β (IL-1β), IL-6, IL-17, tumor necrosis factor-α (TNF-α)] were compared between the two groups before and after treatment. Results The total effective rate in the treatment group was 95.08%, which was significantly higher than that in the control group (83.61%, P < 0.05). After treatment, the periodontal indicators (PD, SBI, PLI, GI) in both groups decreased significantly compared with baseline (P < 0.05), and the above indicators in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of inflammatory cytokines (IL-1β, IL-6, IL-17, TNF-α) in gingival crevicular fluid in both groups decreased significantly compared with baseline (P < 0.05), and the levels of each cytokine in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Longzhang Oral Liquid combined with metronidazole can effectively treat chronic gingivitis, improve periodontal indicators, and inhibit the inflammatory response in gingival crevicular fluid.

辽宁省重点研发计划指导计划（2022045029）