目的 探讨前列安栓联合吲哚美辛治疗慢性非细菌性前列腺炎的临床疗效。方法 纳入2024年1月—2025年12月北京市大兴区中西医结合医院收治的80例慢性非细菌性前列腺炎患者，按照随机数字表法分为对照组和治疗组，每组各40例。对照组给予吲哚美辛栓，直肠给药治疗，1粒/次，1次/d。治疗组在对照组治疗基础上联合前列安栓，1次/d。两组疗程均为4周。观察两组患者临床疗效，比较治疗前后美国国立卫生研究院慢性前列腺炎症状指数（NIH-CPSI）评分、症状评分、简式抑郁–焦虑–压力量表（DASS-21）评分、36项健康调查简表（SF-36）评分及血清C反应蛋白（CRP）水平。结果 治疗后，治疗组总有效率（95.00%）较对照组（80.00%）更高（P＜0.05）。治疗后，两组疼痛不适评分、排尿评分、症状的影响评分、生活质量评分、总评分都低于同组治疗前（P＜0.05）；治疗组疼痛不适评分、排尿评分、症状的影响评分、生活质量评分、总评分低于对照组（P＜0.05）。治疗后，两组尿路症状评分、放射痛症状评分、性功能障碍评分、全身症状评分都降低（P＜0.05）；治疗组临床症状评分低于对照组（P＜0.05）。治疗后，两组DASS-21评分和血清CRP水平都低于同组治疗前，SF-36评分都高于同组治疗前（P＜0.05）；治疗组DASS-21评分和血清CRP水平低于对照组，SF-36评分高于对照组（P＜0.05）。结论 慢性非细菌性前列腺炎采用前列安栓联合吲哚美辛治疗安全性良好，能进一步减轻局部炎症，有效改善患者临床症状、情绪状态及生活质量，值得临床推广应用。

Objective To investigate the clinical efficacy of Qianlie'an Suppositories combined with indomethacin in treatment of chronic non bacterial prostatitis. Methods A total of 80 patients with chronic non-bacterial prostatitis who were admitted to Beijing Daxing Integrated Traditional Chinese and Western Medicine Hospital from January 2024 to December 2025 were included. They were randomly divided into control group and treatment group according to random number table method, with 40 cases in each group. Patients in control group were treated with Indomethacin Suppositories for rectal administration, 1 grain/time, once daily. Patients in treatment group were treated in addition with Qianlie'an Suppositories once daily. Both groups had a treatment course of 4 weeks. The clinical efficacy of two groups was observed, and the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) score, symptom score, Depression Anxiety Stress Scale (DASS-21) score, 36-Item Health Survey (SF-36) score, and serum C-reactive protein (CRP) level before and after treatment were compared. Results After treatment, the total effective rate of the treatment group (95.00%) was higher than that of the control group (80.00%) (P< 0.05). After treatment, the pain discomfort score, urination score, symptom impact score, quality of life score, and total score of both groups were all lower than those before treatment in the same group (P < 0.05). The pain discomfort score, urination score, symptom impact score, quality of life score, and total score of the treatment group were lower than those of control group (P < 0.05). After treatment, the urinary tract symptom score, radiating pain symptom score, sexual dysfunction score, and systemic symptom score of both groups decreased (P < 0.05). The clinical symptom score of treatment group was lower than that of control group (P < 0.05). After treatment, the DASS-21 score and serum CRP level of both groups were lower than those before treatment in the same group, but the SF-36 score was higher than that before treatment (P < 0.05). The DASS-21 score and serum CRP level of treatment group were lower than those of control group, and the SF-36 score was higher than that of control group (P < 0.05). Conclusion The combination of Qianlie'an Suppositories and indomethacin has good safety in treatment of chronic non-bacterial prostatitis, and can further reduce local inflammation, effectively improve the clinical symptoms, emotional state and life quality of patients, which is worthy of clinical promotion and application.

北京中医药薪火传承“3+3”工程（2023-JC-24）