目的 探讨黄藤素软胶囊联合甲硝唑呋喃唑酮栓治疗慢性宫颈炎的临床研究。方法 选取2023年4月—2026年2月在广东医科大学附属东莞第一医院就诊的92例慢性宫颈炎患者，按随机数字表法将患者分为对照组和治疗组，每组各46例。对照组外用甲硝唑呋喃唑酮栓，睡前将药物塞入阴道后穹窿部位，1枚/次，1次/d。治疗组在对照组基础上口服黄藤素软胶囊，4粒/次，3次/d。两组持续治疗1周。比较两组患者的治愈情况、症状改善时间、血清指标。结果 治疗组的治愈率为91.30%，明显高于对照组的治愈率76.09%，差异具有统计学意义（P＜0.05）。治疗组患者下腹痛、外阴瘙痒、阴道异常出血、阴道分泌物增多改善时间均明显短于对照组（P＜0.05）。治疗后，两组患者的血清环氧化酶-2（COX-2）、白细胞介素-12（IL-12）水平明显低于治疗前，血清白细胞介素-2（IL-2）水平明显高于治疗前（P＜0.05）；治疗组治疗后的血清COX-2、IL-12水平明显低于对照组，血清IL-2水平明显高于对照组（P＜0.05）。结论 黄藤素软胶囊联合甲硝唑呋喃唑酮栓可提高慢性宫颈炎的临床疗效，改善临床症状，减轻炎症反应。

Objective To investigate the clinical efficacy of Huangtengsu Soft Capsules combined with Metronidazole and Furazolidone Suppositories in treatment of chronic cervicitis. Methods A total of 92 patients with chronic cervicitis who were treated at The First Affiliated Hospital of Guangdong Medical University, Dongguan from April 2023 to February 2026 were selected. The patients were divided into control group and treatment group, with 46 cases in each group. The control group was administered Metronidazole and Furazolidone Suppositories vaginally before bedtime, with one suppository per time, once daily. The treatment group received oral Huangtengsu Soft Capsules in addition to the control group's regimen, with four capsules per time and three times daily. Two groups were treated for one week. The cure rates, symptom improvement times, and serum indicators were compared between two groups. Results The cure rate of the treatment group was 91.30%, significantly higher than 76.09% of the cure rate in the control group, and the difference was statistically significant (P < 0.05). The improvement time of lower abdominal pain, external genital itching, abnormal vaginal bleeding, and increased vaginal secretion in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the serum levels of cyclooxygenase-2 (COX-2) and interleukin-12 (IL-12) in two groups of patients were significantly reduced, but the serum level of interleukin-2 (IL-2) was significantly increased (P < 0.05). After treatment, the serum levels of COX-2 and IL-12 in the treatment group were significantly lower than those in the control group, but the serum level of IL-2 was significantly higher than that in the control group (P < 0.05). Conclusion Huangtengsu Soft Capsules combined with Metronidazole and Furazolidone Suppository can improve the clinical efficacy of chronic cervicitis, alleviate clinical symptoms, and reduce inflammatory reactions.