目的 探讨保妇康栓联合甲硝唑呋喃唑酮栓治疗慢性宫颈炎的临床疗效。方法 选取2023年6月—2026年1月在保定市第二中心医院就诊的慢性宫颈炎患者共计94例，按随机数字表法分为对照组和治疗组，各包括47例。对照组隔日睡前阴道塞入甲硝唑呋喃唑酮栓，1粒/次。治疗组在对照组治疗的基础上外阴部洗净后塞入保妇康栓，每晚1粒。两组持续治疗30 d。比较两组患者的治疗效果、症状消失时间、阴道清洁度、血清指标。结果 治疗后，对照组、治疗组的治愈率分别为72.34%、89.36%，组间比较差异显著（P＜0.05）。治疗组下腹酸痛、宫颈糜烂、白带异常、接触性出血消失时间均明显短于对照组（P＜0.05）。治疗后，两组的Ⅰ、Ⅱ级阴道清洁度患者数明显增加，Ⅲ、Ⅳ级阴道清洁度患者数明显减少（P＜0.05），且治疗组Ⅰ、Ⅱ级阴道清洁度患者数明显高于对照组，Ⅲ、Ⅳ级阴道清洁度患者数明显低于对照组（P＜0.05）。两组治疗后的血清白细胞介素-2（IL-2）、γ-干扰素（IFN-γ）水平明显升高，血清白细胞介素-8（IL-8）水平明显降低（P＜0.05）；治疗组治疗后的血清IL-2、IFN-γ水平高于对照组，血清IL-8水平低于对照组（P＜0.05）。结论 保妇康栓联合甲硝唑呋喃唑酮栓可提高慢性宫颈炎的疗效，改善临床症状和阴道清洁度，降低炎性损伤。

Objective To investigate the clinical efficacy of Baofukang Suppositories combined with Metronidazole and Furazolidone Suppositories in treatment of chronic cervicitis. Methods A total of 94 patients with chronic cervicitis who were treated at Baoding No.2 Central Hospital from June 2023 to January 2026 were selected and divided into control group and treatment group using a random number table, with 47 cases in each group. The control group was administered Metronidazole and Furazolidone Suppositories vaginally before bedtime every other day, 1 suppository per dose. The treatment group received Baofukang Suppositories inserted vaginally once every night in addition to the control group's regimen. Two groups received continuous treatment for 30 days. The therapeutic effects, symptom disappearance time, vaginal cleanliness, and serum indicators were compared between two groups. Results After treatment, the cure rates in the control group and treatment group were 72.34% and 89.36%, respectively, with a significant difference between two groups (P< 0.05). The disappearance time of lower abdominal pain, cervical erosion, abnormal vaginal discharge, and contact bleeding in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the number of patients with vaginal cleanliness grades I and II significantly increased, while those with grades III and IV significantly decreased in two groups (P < 0.05). Additionally, the treatment group had significantly higher numbers of patients with grades I and II vaginal cleanliness and significantly lower numbers with grades III and IV compared to the control group (P < 0.05). After treatment, serum levels of interleukin-2 (IL-2) and gamma interferon (IFN-γ) in two groups significantly increased, while serum levels of interleukin-8 (IL-8) significantly decreased (P< 0.05). The treatment group exhibited higher serum levels of IL-2 and IFN-γ and lower serum levels of IL-8 compared to the control group after treatment (P< 0.05). Conclusion The combination of Baofukang Suppositories and Metronidazole and Furazolidone Suppositories can enhance the efficacy of chronic cervicitis, improve clinical symptoms and vaginal cleanliness, and reduce inflammatory damage.

保定市科技计划项目（1951ZF036）