目的 评价金振口服液与注射用头孢唑肟钠联合治疗儿童急性支气管炎的临床疗效。方法 选取2024年1月—2025年10月河南医药大学第一附属医院收治的102例急性支气管炎患儿，采用随机数字表法将患儿分为对照组（51例）和治疗组（51例）。对照组静脉滴注注射用头孢唑肟钠50 mg/kg，每12 h给药1次，加入0.9%氯化钠注射液100 mL稀释。治疗组患者在对照组治疗基础上口服金振口服液，1～3岁10 mL/次，2次/d；4～7岁10 mL/次，3次/d；8～12岁15 mL/次，3次/d。两组治疗7 d。比较两组患者的临床疗效、临床症状消失时间、血清炎性介质。结果 治疗组的总有效率96.08%高于对照组80.39%（P＜0.05）。治疗组咳嗽消失时间、完全退热时间、湿啰音消失时间、喘憋消失时间短于对照组（P＜0.05）。治疗后，两组的血清超敏C反应蛋白（hs-CRP）、高迁移率族蛋白B1（HMGB1）、白细胞介素-8（IL-8）、Toll样受体4（TLR4）水平下降（P＜0.05），且治疗组血清hs-CRP、HMGB1、IL-8、TLR4水平低于对照组（P＜0.05）。结论 金振口服液联合注射用头孢唑肟钠治疗儿童急性支气管炎，可有效提升临床疗效，缓解临床症状，降低炎症反应。

Objective To evaluate the clinical efficacy of Jinzhen Oral Liquid combined with Cefotaxime Sodium for injection in treatment of acute bronchitis in children. Methods 102 Children with acute bronchitis admitted to The First Affiliated Hospital of Henan Medical University from January 2024 to October 2025 were selected and divided into control group (51 cases) and treatment group (51 cases) using a random number table method. The control group received iv 50 mg/kg Cefotaxime Sodium for injection, administered once every 12 h, diluted with 100 mL of 0.9% sodium chloride injection. The treatment group received oral Jinzhen Oral Liquid on the basis of the control group treatment, with a dosage of 10 mL/time, twice daily for 1 — 3 years old, 10 mL/time, 3 times daily for 4 — 7 years old, and 15 mL/time, 3 times daily for 8 — 12 years old. The two groups were treated for 7 d. The clinical efficacy, disappearance time of clinical symptoms, and serum inflammatory mediators were compared between two groups. Results The total effective rate 96.08% of the treatment group was higher than 80.39% of the control group (P < 0.05). The treatment group had shorter cough disappearance time, complete fever reduction time, wet rales disappearance time, and wheezing disappearance time than that of the control group (P< 0.05). After treatment, the serum levels of high-sensitivity C-reactive protein (hs-CRP), high mobility group protein B1 (HMGB1), interleukin-8 (IL-8), and Toll like receptor 4 (TLR4) decreased in two groups (P < 0.05), and the serum levels of hs-CRP, HMGB1, IL-8, and TLR4 in the treatment group were lower than those in the control group (P < 0.05). Conclusion The combination of Jinzhen Oral Liquid and Cefotaxime Sodium for injection in treatment of acute bronchitis in children can effectively improve clinical efficacy, alleviate clinical symptoms, and reduce inflammatory reactions.

河南省医学科技攻关计划联合共建项目（LHGJ20230520）