目的 探寻苏合香丸联合尼可地尔治疗冠心病经皮冠状动脉介入术（PCI）后心绞痛患者的临床疗效。方法 选取2023年1月—2024年12月武汉市中医医院收治的60例冠心病PCI术后心绞痛患者，采用随机数字表法将纳入患者分为对照组和治疗组，各30例。对照组口服尼可地尔片，5 mg/次，3次/d。治疗组患者在对照组基础上口服苏合香丸，每次1丸，2次/d。两组患者均连续治疗1个月。观察两组临床疗效和心绞痛发作情况，比较中医证候积分、西雅图心绞痛量表（SAQ）评分、运动耐力相关指标。结果 治疗后，治疗组总有效率（93.33%）显著高于对照组（73.33%，P＜0.05）。治疗后两组患者发作频率、发作持续时间均显著低于治疗前（P＜0.05），且治疗组发作频率及发作持续时间低于对照组（P＜0.05）。治疗后，两组患者中医证候积分较前显著降低，躯体受限程度评分、心绞痛稳定状况评分、心绞痛发作情况评分、治疗满意度评分、疾病认知度评分显著升高（P＜0.05）；治疗后，治疗组中医证候积分低于对照组，躯体受限程度评分、心绞痛稳定状况评分、心绞痛发作情况评分、治疗满意度评分、疾病认知度评分高于对照组（P＜0.05）。治疗后，两组患者心电图平板运动（TET）试验总时间、最大负荷量（METs）、METs时心率均明显高于治疗前（P＜0.05），且治疗后治疗组TET总时间、METs、METs时心率均高于对照组（P＜0.05）。结论 苏合香丸联合尼可地尔片治疗冠心病PCI术后心绞痛患者效果较好，利于缓解患者心绞痛发作程度，缩短发作持续时间，改善患者生活质量，提高运动耐力，值得临床推广应用。

Objective To explore the clinical efficacy of Suhexiang Pills combined with nicorandil in treatment of coronary heart disease angina pectoris after percutaneous coronary intervention (PCI). Methods Sixty patients with angina pectoris after PCI who were admitted to Wuhan Traditional Chinese Medicine Hospital from January 2023 to December 2024 were selected. The patients were divided into control group and treatment group by using random number table method, with 30 cases in each group. Patients in control group were given Nicorandil Tablets, 5 mg each time, 3 times daily. Patients in treatment group patients were given Suhexiang Pills orally on basis of control group, 1 pill each time, twice daily. Both groups of patients were treated continuously for 1 month. The clinical efficacy and angina pectoris attack conditions of two groups were observed, and the TCM syndrome scores, Seattle Angina Questionnaire (SAQ) scores, and exercise endurance related indicators were compared. Results After treatment, the total effective rate of treatment group (93.33%) was significantly higher than that of control group (73.33%, P < 0.05). After treatment, the frequency and duration of attacks in both groups were significantly lower than those before treatment (P < 0.05), and the frequency and duration of attacks in treatment group were lower than those in control group (P < 0.05). After treatment, the scores of traditional Chinese medicine syndromes in both groups significantly decreased compared with those before treatment, but the scores of physical restriction degree, stable condition of angina pectoris, angina pectoris attack situation, treatment satisfaction, and disease cognition significantly increased (P < 0.05). After treatment, the scores of traditional Chinese medicine syndromes in treatment group were lower than those in control group, but the scores of physical restriction degree, stable condition of angina pectoris, angina pectoris attack situation, treatment satisfaction, and disease cognition were higher in treatment group than in the control group (P < 0.05). After treatment, the total time of the treadmill exercise test (TET), maximum load (METs), and heart rate during METs in both groups were significantly higher than those before the treatment (P < 0.05), and the total time of TET, METs, and heart rate during METs in treatment group were higher than those in control group after treatment (P < 0.05). Conclusions The combination of Suhexiang Pills and Nicorandil Tablets has a better therapeutic effect on patients with angina pectoris after PCI for coronary heart disease. It helps to alleviate the severity of angina attacks, shorten the duration of attacks, improve the quality of life of patients, and enhance their exercise endurance, which is worthy of clinical promotion and application.

湖北省科学技术厅项目（2022CFC002）