目的 采用多指标成分定量结合化学计量学评价腰息痛胶囊的质量。方法 采用HLPC法测定腰息痛胶囊中水合氧化前胡素、白当归素、佛手柑内酯、欧前胡素和异欧前胡素，结合聚类分析、主成分分析、偏最小二乘法评价腰息痛胶囊质量。结果 腰息痛胶囊样品分为3类，同厂家不同批次间样品差异不明显，不同厂家存在差异性。3个主成分的累积方差贡献率达到96.935%，筛选出质量差异标志物为水合氧化前胡素、佛手柑内酯和欧前胡素。结论 方法简单可靠，可评价腰息痛胶囊的质量。

Objective To evaluate quality of Yaoxitong Capsules by multi-index component determination combined with chemometrics. Methods The quantitative analysis of oxypeucedanin hydrate, byakangelicin, bergapten, imperatorin, and isoimperatorin in Yaoxitong Capsules was carried out by HPLC method, and the quality of Yaoxitong Capsules was evaluated by cluster analysis, principal component analysis, and partial least squares method. Results Yaoxitong Capsules were classified into 3 categories, and there were no significant differences among samples from different batches within the same manufacturer, whereas variability was noted among different manufacturers. The cumulative variance contribution of the three principal components reached 96.935%, and the quality difference markers were identified as oxypeucedanin hydrate, bergapten, imperatorin. Conclusion The method is simple and reliable, and can evaluate the quality of Yaoxitong Capsules.

河北省中医药管理局科技项目（2023ZC1004）