目的 采用超高效液相-四级杆串联飞行时间质谱（UPLC-Q-TOF-MS）法对感冒解毒颗粒所含化学成分进行鉴定。方法 采用UPLC-Q-TOF-MS技术和Peakview软件对感冒解毒颗粒进行数据采集和数据处理，结合国内外相关文献、对照品二级质谱库鉴定感冒解毒颗粒中化学成分。结果 鉴定或推断了其中50个化合物的结构，其中包括20个香豆素类化合物，17个黄酮类化合物，3个酚酸类化合物，3个苷类化合物，1个醌类化合物，其余木脂素类、有机酸类和萜类成分共6种。结论 方法简洁高效，准确度高，为感冒解毒颗粒中化学成分的鉴定提供了方法。

Objective To identify the chemical components in Ganmao Jiedu Granules using UPLC-Q-TOF-MS technology. Methods UPLC-Q-TOF-MS technology and Peakview software were used to collect and process data in Ganmao Jiedu Granules. The chemical composition in Ganmao Jiedu Granules was identified by combining relevant literature and reference material secondary mass spectrometry libraries at home and abroad. Results The structures of 50 compounds were identified or inferred, including 20 coumarin compounds, 17 flavonoids, 3 phenolic acid compounds, 3 glycoside compounds, 1 quinone, and the remaining 6 types comprising lignans, organic acids, and terpenoids. Conclusion The method is simple, efficient, and highly accurate, providing a means for the identification of chemical components in Ganmao Jiedu Granules.

国家药品标准制修订研究课题（2023Z074）