脂肪肝与酒精、肥胖、高血压、糖尿病、代谢综合征、心血管疾病密切相关，近年来发病率呈上升趋势，且年轻化加重。丹皮酚是由牡丹皮提取的酚类化合物，可通过调脂作用、抑制脂滴形成和积累、减轻炎症反应、减轻氧化应激反应、抑制肝纤维化、调节肠道菌群发挥抗脂肪肝的作用。总结了丹皮酚治疗脂肪肝的药理作用研究进展，为丹皮酚治疗脂肪肝的临床应用提供参考。

Fatty liver is closely related to alcohol, obesity, hypertension, diabetes, metabolic syndrome. In recent years, the incidence rate of fatty liver is on the rise and getting younger. Paeonol is a phenolic compound extracted from Moutan Cortex. Paeonol can exert anti-fatty liver effects by regulating lipid levels, inhibiting lipid droplet formation and accumulation, reducing inflammatory reactions, alleviating oxidative stress reactions, inhibiting liver fibrosis, and regulating intestinal flora. This article summarizes the research progress on the pharmacological effects of paeonol in treatment of fatty liver, providing reference for the clinical application of paeonol in treatment of fatty liver.

R977

保定市科技计划项目（2041ZF115）