子宫内膜癌是女性生殖系统常见恶性肿瘤，目前临床对子宫内膜癌治疗以化疗、激素、靶向治疗为主。雷公藤甲素是由雷公藤中提取的环氧二萜内酯化合物，可通过抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、抑制肿瘤细胞侵袭和转移、抑制肿瘤血管形成、克服化疗耐药性限制子宫内膜癌的生长，发挥有效的抗肿瘤活性。总结了雷公藤甲素防治子宫内膜癌的药理作用研究进展，为雷公藤甲素临床防治子宫内膜癌提供参考。

Endometrial cancer is a common malignant tumor of the female reproductive system. At present, the clinical treatment of endometrial cancer mainly includes chemotherapy, steroids, and targeted therapy. Triptolide is an epoxy diterpenoid lactone extracted from Tripterygii Radix et Rhizoma, and can limit the growth of endometrial cancer and exert effective anti-tumor activity by inhibiting tumor cell proliferation, promoting tumor cell apoptosis, inhibiting tumor cell invasion and metastasis, inhibiting tumor angiogenesis, overcoming chemotherapy resistance. This article summarizes the pharmacological research progress of triptolide in prevention and treatment of endometrial cancer, providing reference for the clinical prevention and treatment of endometrial cancer with triptolide.

R979.1

江苏省卫生健康委科研项目（H2023113）