骨缺损是骨科最具挑战性的疾病之一，治疗周期长，其修复机制的核心在于细胞分化协同、免疫微环境平衡、信号通路整合等多维度调控，临床治疗难度较大。葛根素可通过促进成骨细胞增殖与分化、抑制破骨细胞活性、改善炎症微环境、改善氧化微环境、促进血管生成调节骨形成和骨吸收平衡，促进骨缺损修复。总结了葛根素促进骨缺损修复的药理作用研究进展，为葛根素临床治疗骨缺损提供参考。

Bone defect is one of the most challenging orthopedic diseases, with a long treatment cycle. The core of bone defect repair mechanism lies in multidimensional regulation such as cell differentiation coordination, immune microenvironment balance, and signal pathway integration, and makes clinical treatment more difficult. Puerarin can promote the proliferation and differentiation of osteoblasts, inhibit osteoclast activity, improve the inflammatory microenvironment, enhance the oxidative microenvironment, promote angiogenesis, regulate bone formation and resorption balance, and promote bone defect repair. This article summarizes the pharmacological research progress of puerarin in promoting bone defect repair, providing reference for the clinical treatment of bone defects with puerarin.

R286.7

天津市科技计划项目（22JCYBJC00210）