胃癌是常见的消化系统肿瘤，发病率和死亡率均位居恶性肿瘤前列，以化疗、放疗、靶向治疗和免疫治疗等为主。他汀类药物是3-羟基-3-戊二酰辅酶A还原酶的抑制剂，通过抑制癌细胞增殖、诱导癌细胞凋亡、抑制胃癌细胞侵袭和转移、抑制幽门螺杆菌中的细胞毒素相关基因A的易位/磷酸化、抑制YAP和β-catenin信号传导阻碍胃癌的发生、发展，发挥抗肿瘤作用。他汀类药物在临床治疗中可增强化疗、放疗、靶向治疗和免疫治疗的疗效，降低胃癌的发生率和病死率。对他汀类药物治疗胃癌的作用机制和临床应用进行总结，以指导临床实践。

Gastric cancer is a common tumor of the digestive system, and its incidence rate and mortality rate are among the top of malignant tumors, mainly including chemotherapy, radiotherapy, targeted therapy and immunotherapy. Statins are 3-hydroxy-3-glutaryl-coenzyme reductase inhibitors, and exert anti-tumor effects by inhibiting cancer cell proliferation, inducing cancer cell apoptosis, suppressing gastric cancer cell invasion and metastasis, inhibiting the translocation/phosphorylation of cytotoxin related gene A in Helicobacter pylori, inhibiting YAP and β-catenin signaling, and hindering the occurrence and development of gastric cancer. Statins can enhance the efficacy of chemotherapy, radiotherapy, targeted therapy, and immunotherapy in clinical treatment, and reduce the incidence and mortality of gastric cancer. This article summarizes the mechanism and clinical application of statins in treatment of gastric cancer, in order to guide clinical practice.

R979.1

甘肃省自然科学基金项目（23JRRA1288）