柴胡皂苷是从柴胡中提取的皂苷衍生物，具有多种药理作用。柴胡皂苷可通过多种途径对肝脏产生保护作用，如抗炎、调节肝脏代谢、抗肝纤维化、抗肝癌、抗氧化应激、调节细胞凋亡。总结了柴胡皂苷对肝脏保护作用机制的研究进展，以期为肝脏疾病的新药开发和临床应用提供参考和借鉴。

Saikosaponins are saponin derivatives extracted from Bupleuri Radix and have various pharmacological effects. Saikosaponins have hepatoprotective effects through various pathways, such as anti-inflammatory actions, regulating hepatic metabolism, anti-liver fibrosis, anti-hepatic cancer, antioxidant stress, and regulating cell apoptosis. This article summarizes the research progress on the hepatoprotective mechanisms of saikosaponins, in order to provide reference and guidance for the development and clinical application of new drugs for liver diseases.

R286.5

国家自然科学基金资助项目（81603418、82074271）；黑龙江省优秀青年人才项目（2020YQ05）；黑龙江中医药大学研究生创新科研项目立项（2024yjscx124）