目的 探讨泌淋胶囊联合头孢泊肟酯治疗尿路感染的临床疗效。方法 回顾性选取2021年1月—2024年1月聊城市第二人民医院泌尿科收治的100例尿路感染患者临床资料，根据用药方案差异将患者分为对照组50例和治疗组50组。对照组患者口服头孢泊肟酯片，0.1 g/次，2次/d。治疗组在对照组的基础上口服泌淋胶囊，3粒/次，每日3次。两组用药2周。观察两组的疗效；比较两组中医症状积分、血白细胞计数（WBC）、尿白细胞（WBC）、血C反应蛋白（CRP）水平。结果 治疗14 d后，与对照组82.00%的总有效率比较，治疗组总有效率96.00%较高（P＜0.05）。治疗后，两组小便灼热评分、小便频数评分、腰部酸痛评分、小便涩痛评分均降低（P＜0.05）；治疗后，与对照组对比，治疗组小便灼热评分、小便频数评分、腰部酸痛评分、小便涩痛评分均较低（P＜0.05）。治疗后，两组血WBC、尿WBC、血CRP指标显著降低（P＜0.05）；治疗后，与对照组对比，治疗组血WBC、尿WBC、血CRP指标均较低（P＜0.05）。结论 泌淋胶囊联合头孢泊肟酯协同治疗尿路感染效果较佳，可缩短尿道感染病程，降低机体炎症反应，且药物安全，值得借鉴与应用。

Objective To explore the therapeutic effect of Milin Capsules combined with cefpodoxime proxetil in treatment of urinary tract infections.Methods The clinical data of 100 patients with urinary tract infections admitted to the Department of Urology of Liaocheng Second People’s Hospital from January 2021 to January 2024 were retrospectively selected. According to the differences in medication regimens, the patients were divided into control group of 50 cases and treatment group of 50 cases. Patients in control group took Cefpodoxime Proxetil Tablets orally, 0.1g each time, twice daily. Patients in treatment group took Milin Capsules orally on the basis of control group, 3 capsules each time, 3 times daily. The two groups were administered medication for 2 weeks. The therapeutic effects of two groups was observed, and the TCM symptom scores, white blood cell count (WBC), urine WBC, and blood C-reactive protein (CRP) levels were compared between two groups.Results After 14 d of treatment, compared with the total effective rate of 82.00% in control group, the total effective rate of 96.00% in treatment group was higher (P < 0.05). After treatment, the scores of burning sensation during urination, frequency of urination, lumbar soreness and painful urination in two groups decreased (P < 0.05). After treatment, compared with the control group, the scores of burning sensation during urination, frequency of urination, lumbar soreness and painful urination in treatment group were lower (P < 0.05). After treatment, the indicators of blood WBC, urine WBC, and blood CRP in both groups decreased significantly (P < 0.05). After treatment, compared with control group, the indicators of blood WBC, urine WBC, and blood CRP in treatment group were all lower (P < 0.05).Conclusion Milin Capsules combined with cefpodoxime proxetil has a better effect in treatment of urinary tract infections, and can shorten the course of urinary tract infections, reduce the inflammatory response of body, and the drug is safe. It is worthy of reference and application.

R983

聊城市重点研发计划政策引导类项目（2023YD48）