目的 探讨清咳平喘颗粒联合注射用头孢米诺钠治疗社区获得性肺炎的临床疗效。方法 回顾性分析天津中医药大学第二附属医院在2024年1月～8月就诊的150例社区获得性肺炎患者的临床资料，150例患者按随机数字表法分为对照组和治疗组，每组75例。对照组静滴注射用头孢米诺钠，2次/d，1.0 g/次。治疗组在对照组基础上温水冲服清咳平喘颗粒，3次/d，1袋/次。两组持续治疗10 d。比较两组的临床疗效、症状改善情况、影像学吸收评分、血清指标。结果 对照组患者的总有效率为82.67%，治疗组的总有效率为94.67%，组间比较差异显著（P＜0.05）。治疗组患者退热时间、止咳时间、肺啰音消失时间、咯痰消失时间均比对照组短（P＜0.05）。治疗后，两组的影像学吸收评分显著减小（P＜0.05），且治疗组的影像学吸收评分比对照组更小（P＜0.05）。两组治疗后的血清CXC趋化因子配体10（CXCL10）、基质金属蛋白酶-2（MMP-2）、正五聚蛋白3（PTX3）水平均低于治疗前（P＜0.05）；治疗组治疗后的血清CXCL10、MMP-2、PTX3水平低于对照组（P＜0.05）。结论 清咳平喘颗粒联合注射用头孢米诺钠可提高社区获得性肺炎的临床疗效，促进症状改善，降低炎症反应。

Objective To investigate the clinical efficacy of Qingke Pingchuan Granules combined with Cefminox Sodium for injection in treatment of community-acquired pneumonia.Methods Retrospective analysis of clinical data of 150 patients with community-acquired pneumonia who visited the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from January to August 2024 was carried on. All 150 patients were divided into control group and treatment group using a random number table method, with 75 patients in each group. The control group patients received intravenous infusion of Cefminox Sodium for injection, twice daily, with a dose of 1.0 g each time. On the basis of the control group, patients in the treatment group were po administered with Qingke Pingchuan Granules diluted with warm water, three times daily, with one bag each time. The clinical efficacy, symptom improvement, imaging absorption score, and serum indicators between two groups of patients were compared.Results The total effective rate of the control group (94.67%) was significantly lower than that of the treatment group (82.67%), and the difference between the groups was significant (P < 0.05). The treatment group had lower fever reduction time, cough suppression time, disappearance time of lung rales, and disappearance time of expectoration compared to the control group (P < 0.05). After treatment, the imaging absorption scores of both groups were significantly decreased (P < 0.05), and the imaging absorption scores of the treatment group were smaller than those in the control group (P < 0.05). The serum levels of CXCL10, MMP-2, and PTX3 in both groups after treatment were lower than those before treatment (P < 0.05), and the serum levels of CXCL10, MMP-2, and PTX3 in the treatment group were lower than those in the control group after treatment (P < 0.05).Conclusion The combination of Qingke Pingchuan Granules and Cefminox Sodium for injection can improve the clinical efficacy of community-acquired pneumonia, promote symptom improvement, reduce inflammatory reactions.

R974

国家自然科学基金资助项目（82104800）；天津市教委科研计划项目（2024ZD011）；天津市教委科研计划项目（2021ZD018）；天津市中医药重点领域科研项目（2022010）