目的 探讨肺宁颗粒联合乙酰半胱氨酸泡腾片治疗特发性肺间质纤维化的临床疗效。方法 选取2021年4月—2023年12月邢台市人民医院收治的特发性肺间质纤维化患者108例，按随机数字表法将患者分为对照组和治疗组，每组各54例。对照组口服乙酰半胱氨酸泡腾片，0.6 g/次，2次/d。在对照组基础上，治疗组口服肺宁颗粒，1袋/次，3次/d。两组患者疗程为3个月。观察两组患者临床疗效，比较治疗前后两组患者肺功能指标和血气分析，6 min步行距离（6MWD）和圣乔治呼吸问卷（SGRQ）评分，血清基质金属蛋白酶-9（MMP-9）、转化生长因子-β1（TGF-β1）、纤溶酶原激活剂抑制剂-1（PAI-1）和白细胞介素-13（IL-13）水平。结果 治疗后，治疗组患者总有效率明显高于对照组（92.59% vs 77.78%，P＜0.05）。治疗后，两组一氧化碳弥散量（DLCO）、肺总量（TLC）、潮气量（VC）、动脉氧分压（pO₂）和动脉血氧饱和度（SaO₂）水平明显高于组内治疗前（P＜0.05），且治疗组这些指标水平显著高于对照组（P＜0.05）。治疗后，两组6MWD比治疗前显著增加，而SGRQ评分显著减少（P＜0.05），且治疗组6MWD、SGRQ评分明显好于对照组（P＜0.05）。治疗后，两组患者血清MMP-9、TGF-β1、PAI-1、IL-13水平均低于同组治疗前（P＜0.05），且治疗后治疗组患者血清因子水平明显低于对照组（P＜0.05）。结论 采用肺宁颗粒联合乙酰半胱氨酸泡腾片治疗特发性肺间质纤维化，安全性较好，能有效抑制机体炎症状态及肺纤维化，恢复患者肺功能、呼吸功能及运动耐力，利于患者生活质量的改善。

Objective To investigate the clinical efficacy of Feining Granules combined with acetylcysteine in treatment of idiopathic pulmonary interstitial fibrosis.Methods Patients (108 cases) with idiopathic pulmonary interstitial fibrosis in Xingtai People′s Hospital from April 2021 to December 2023 were divided into control and treatment group according to random number table method, and each group had 54 cases. Patients in the control group were po administered with Acetylcysteine Effervescent Tablets, 0.6 g/time, twice daily. Patients in the treatment group were po administered with Feining Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical evaluations were evaluated, and the lung function indicators and blood gas analysis, 6MWD and SGRQ scores, serum MMP-9, TGF-β1, PAI-1, and IL-13 levels in two groups before and after treatment were compared.Results After treatment, the clinical total effective rate in the treatment group was significantly higher than that in the control group (92.59% vs 77.78%, P < 0.05). After treatment, the levels of DLCO, TLC, VC, pO₂ and SaO₂ in two groups were significantly higher than those before treatment in the two groups (P < 0.05), and the levels of these indicators in the treatment group were significantly higher than those in the control group (P < 0.05). After treatment, 6MWD in two groups were significantly increased compared with before treatment, while SGRQ score was significantly decreased (P < 0.05), and the score in the treatment group was significantly better than that in the control group (P < 0.05). After treatment, the serum levels of MMP-9, TGF-β1, PAI-1, and IL-13 in two groups were lower than those before treatment in the same group (P < 0.05), and the serum factor levels in the treatment group were significantly lower than those in the control group (P < 0.05).Conclusion The treatment of idiopathic pulmonary interstitial fibrosis with Feining Granules combined with Acetylcysteine Effervescent Tablets has good safety, can effectively inhibit the inflammatory state and pulmonary fibrosis of the body, restore the patient's lung function, respiratory function and exercise endurance, and improve the patient′s quality of life.

R974

邢台市科学技术委员会医学创新研究专项（20Y115668）