肝纤维化是多种慢性肝病必经的病理进程和病理结果，最终进展为肝硬化。氧化苦参碱是由苦参中提取的生物碱，具有强效抗炎活性，可通过抑制肝星状细胞的活力，减轻炎症反应，降低氧化应激反应，抑制成纤维细胞活性，抑制Ⅰ型前胶原的沉积，调节肠道菌群，抑制细胞外基质的过度沉积，多靶点调控基因表达发挥抗肝纤维化作用。总结了氧化苦参碱抗肝纤维化的研究，归纳其作用机制，为氧化苦参碱的临床应用提供思路。

Liver fibrosis is a necessary pathological process and outcome in various chronic liver diseases, ultimately leading to cirrhosis. Oxymatrine is an alkaloid extracted from Sophorae Flavescentis Radix, which has potent anti-inflammatory activity, and can exert anti liver fibrosis effects by inhibiting the activity of hepatic stellate cells, reducing inflammatory responses, lowering oxidative stress responses, suppressing fibroblast activity, inhibiting the deposition of type I procollagen, regulating intestinal flora, inhibiting excessive deposition of extracellular matrix, and multi-target regulation of gene expression. This article summarizes the research on oxymatrine against liver fibrosis, summarizes its mechanism, and provides ideas for the clinical application of oxymatrine.

R965;R975

海南省卫生计生行业科研项目（19A200135）