骨质疏松症目前已成为全球首要公共卫生问题之一，不仅增加患者骨折的风险，还给家庭和社会带来沉重的负担，提高骨质疏松症的防治效果成为广大医师研究的热点。异补骨脂素是由补骨脂中提取的脂溶性物质，可通过促进成骨细胞增殖和分化、抑制破骨细胞增殖和活性、双向调节骨代谢、促进成骨相关基因的表达、发挥雌激素样活性发挥抗骨质疏松作用。总结了异补骨脂素抗骨质疏松的药理作用研究进展，总结其作用机制，为异补骨脂素的临床应用提供参考。

Osteoporosis has become one of the world's top public health issues. It not only increases the risk of fractures in patients, but also brings a heavy burden to families and society. Improving the prevention and treatment of osteoporosis has become a hot topic for many physicians. Isopsoralen is a lipophilic substance extracted from Psoraleae Fructus. Isopsoralen can promote osteoblast proliferation and differentiation, inhibit osteoclasts proliferation and activity, bidirectionally regulate bone metabolism, promote the expression of osteogenic-related genes, and exert estrogen-like activity to exert anti-osteoporosis effects. This article summarizes the research progress on the pharmacological effects of isopsoralen against osteoporosis, summarizes its mechanism of action, and provides reference for the clinical application of isopsoralen.

R965;R982

广东省基础与应用基础研究基金项目（2020B1515120052）