[关键词]
[摘要]
骨质疏松症目前已成为全球首要公共卫生问题之一,不仅增加患者骨折的风险,还给家庭和社会带来沉重的负担,提高骨质疏松症的防治效果成为广大医师研究的热点。异补骨脂素是由补骨脂中提取的脂溶性物质,可通过促进成骨细胞增殖和分化、抑制破骨细胞增殖和活性、双向调节骨代谢、促进成骨相关基因的表达、发挥雌激素样活性发挥抗骨质疏松作用。总结了异补骨脂素抗骨质疏松的药理作用研究进展,总结其作用机制,为异补骨脂素的临床应用提供参考。
[Key word]
[Abstract]
Osteoporosis has become one of the world's top public health issues. It not only increases the risk of fractures in patients, but also brings a heavy burden to families and society. Improving the prevention and treatment of osteoporosis has become a hot topic for many physicians. Isopsoralen is a lipophilic substance extracted from Psoraleae Fructus. Isopsoralen can promote osteoblast proliferation and differentiation, inhibit osteoclasts proliferation and activity, bidirectionally regulate bone metabolism, promote the expression of osteogenic-related genes, and exert estrogen-like activity to exert anti-osteoporosis effects. This article summarizes the research progress on the pharmacological effects of isopsoralen against osteoporosis, summarizes its mechanism of action, and provides reference for the clinical application of isopsoralen.
[中图分类号]
R965;R982
[基金项目]
广东省基础与应用基础研究基金项目(2020B1515120052)