糖尿病是临床最常见的代谢性疾病，是心血管疾病的独立危险因素。临床防治糖尿病心肌损伤的药物作用机制较单一。小檗碱可通过降低血糖、调节心肌脂质代谢、改善心肌细胞能量代谢、减轻炎症反应、增强抗氧化作用、降低心肌细胞凋亡、减轻心律失常、延缓心肌重塑、促进新血管形成多途径、多靶点降低高糖引起的心肌损伤，发挥心肌保护作用。综述了小檗碱对糖尿病心肌损伤的保护作用，为小檗碱的临床应用提供理论依据。

Diabetes is the most common metabolic disease in clinic and an independent risk factor for cardiovascular disease. The mechanism of drugs for treating myocardial injury in diabetes is relatively simple. Berberine can reduce myocardial injury caused by high glucose through multiple pathways and multiple targets by lowering blood sugar, regulating myocardial lipid metabolism, improving myocardial cell energy metabolism, alleviating inflammatory response, enhancing antioxidant effect, reducing myocardial cell apoptosis, alleviating arrhythmia, delaying myocardial remodeling, and promoting neovascularization. This article reviews the protective effect of berberine on diabetic myocardial injury, and provides theoretical basis for clinical application of berberine.

R286.2

北京市医院管理中心青年人才培养“青苗”计划（QML20232224）