帕金森病是全球第2大影响老年人的神经退行性病变，发病机制复杂，目前尚缺乏根治方式。木犀草素可通过降低炎症反应、减轻氧化应激反应、降低突变蛋白的神经毒性、抑制神经细胞凋亡、保护多巴胺能神经元多靶点、多途径发挥防治帕金森病的作用。综述了木犀草素防治帕金森病的药理作用研究进展，为帕金森病的药物治疗提供参考。

Parkinson's disease is the second largest neurodegenerative disease affecting the elderly worldwide, with a complex pathogenesis and currently lacking a cure. Luteolin can prevent and treat Parkinson's disease by reducing inflammation, alleviating oxidative stress, reducing neurotoxicity of mutant proteins, alleviating neuronal apoptosis, and protecting dopaminergic neurons through multiple targets and pathways. This article reviews the pharmacological research progress of luteolin in prevention and treatment of Parkinson's disease, providing reference for drug therapy of Parkinson's disease.

R286.1

黑龙江省中医药科研项目（ZYW2023-111）；国家中医药管理局全国名老中医药专家传承工作室建设项目（国中医药人教涵〔2022〕75号）