智能给药系统结合了缓控释制剂和靶向制剂的优点，能根据特定的生理或环境信号动态调节药物释放速率，近年来逐渐成为研究热点。智能给药系统可通过pH值、酶、氧化还原、氧、葡萄糖等内源性响应型或温、光、磁、超声等外源性响应型以及pH值/酶、pH值/氧化还原双重响应型等多模态响应型触发药物的释放，递药载体包括凝胶剂、微针贴片、纳米载体，在眼部给药、鼻腔给药、经皮给药、口服给药、注射给药、阴道给药等多种给药途径中应用。梳理了智能给药系统的响应机制、载体设计的临床应用，论证智能给药系统的实际临床应用价值。

Intelligent drug delivery system (IDDS) combines the advantages of slow-release and targeted drugs, and can dynamically adjust the drug release rate based on specific physiological or environmental signals. In recent years, IDDS has gradually become a research hotspot. IDDS can trigger drug release through endogenous response types (including pH value enzyme, redox, oxygen, and glucose response), exogenous response types (including temperature, light, magnetic, and ultrasound response), and multimodal response types (including pH/enzyme and pH/redox dual response types). Drug delivery carriers of IDDS include gel, microneedle patch and nano carrier, which are used in various drug delivery routes such as eye administration, nasal administration, transdermal administration, oral administration, injection administration, and vaginal administration. This article summarizes the response mechanism of DDS, the clinical application of carrier design, and demonstrates the practical clinical value of DDS.

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