高尿酸血症是一种慢性代谢性疾病，现有的临床治疗药物主要以控制尿酸水平为目标。植物雌激素是一类存在于植物中的具有弱雌激素作用的杂环多酚类化合物，可以通过抑制黄嘌呤氧化酶、促进尿酸排泄转运蛋白的表达和活性、抑制尿酸重吸收蛋白表达、改善肠道菌群多样性防治高尿酸血症，同时防治高尿酸血症并发症高血压、动脉粥样硬化和代谢相关脂肪性肝病。总结了植物雌激素防治高尿酸血症及其并发症的研究进展，为植物雌激素防治高尿酸血症的临床应用提供参考。

Hyperuricemia is a chronic metabolic disease, and existing clinical treatment drugs mainly aim to control uric acid levels. Phytoestrogens are a class of heterocyclic polyphenolic compounds that exist in plants and have weak estrogenic effects. Phytoestrogens can prevent and treat hyperuricemia by inhibiting xanthine oxidase, promoting the expression and activity of uric acid excretion transporter, inhibiting the expression of uric acid reabsorption protein, improving the diversity of intestinal flora, and preventing and treating hyperuricemia complications such as hypertension, arterial atherosclerosis and metabolism related fatty liver disease. This article summarizes the research progress on phytoestrogens in prevention and treatment of hyperuricemia and its complications, providing reference for the clinical application of phytoestrogens in prevention and treatment of hyperuricemia.

R282.71

天津市中医药重点领域科研项目（2024009）；新疆维吾尔自治区科技计划项目（2022LQ04007）