目的 探讨口腔炎喷雾剂联合更昔洛韦分散片治疗疱疹性口炎的临床疗效。方法 将2023年1月—2024年12月南京大学医学院附属口腔医院第五门诊部收治的104例疱疹性口炎患者作为研究对象，按随机数字表法将患者分为对照组和治疗组，各52例。对照组患者随食物口服更昔洛韦分散片，4片/次，3次/d。治疗组在对照组基础上每次向口腔患处喷口腔炎喷雾剂1 mL，3次/d。两组持续治疗2周。比较两组的治疗疗效、症状改善时间、黏膜损伤面积和血清指标。结果 对照组的总有效率为82.69%，治疗组的总有效率为96.15%，组间比较差异有统计学意义（P＜0.05）。治疗组高热、疱疹、疼痛、拒食改善时间均短于对照组（P＜0.05）。治疗后，两组的黏膜损伤面积显著缩小（P＜0.05），治疗组的黏膜损伤面积小于对照组（P＜0.05）。治疗后，两组的血清总蛋白升高，前白蛋白、单纯疱疹病毒-免疫球蛋白M（HSV-IgM）降低（P＜0.05）；治疗组的血清总蛋白水平高于对照组，血清前白蛋白、HSV-IgM水平低于对照组（P＜0.05）。结论 口腔炎喷雾剂联合更昔洛韦分散片可提高疱疹性口炎的治疗效果，改善临床症状，减轻炎症反应，提高免疫功能。

Objective To explore the clinical efficacy of Kouqiangyan Spray combined with Ganciclovir Dispersible Tablets in treatment of herpetic stomatitis. Methods A total of 104 patients with herpetic stomatitis in The Fifth Outpatient Department of the Affiliated Stomatological Hospital of Nanjing University Medical School from January 2023 to December 2024 were divided into control group and treatment group according to the random number table method, with 52 cases in each group. Patients in the control group patients were po administered with Ganciclovir Dispersible Tablets with food, 4 tablets/time, 3 times daily. On the basis of the control group, patients in the treatment group sprayed Kouqiangyan Spray to the affected area, 1 mL/time, 3 times daily. Two groups received continuous treatment for 2 weeks. The treatment efficacy, symptom improvement time, mucosal injury area, and serum indicators were compared between the two groups. Results The total effective rate of the control group was 82.69%, while the total effective rate of the treatment group was 96.15%, and the difference between the groups was statistically significant (P < 0.05). The improvement time of high fever, herpes, pain, and food refusal in the treatment group was shorter than that in the control group (P < 0.05). After treatment, the mucosal lesion areas of both groups were significantly decreased (P < 0.05), and the mucosal lesion areas of the treatment group were smaller than those of the control group (P < 0.05). After treatment, the serum levels of total serum protein in both groups were increased, but serum level of prealbumin and HSV-IgM were decreased (P < 0.05). The serum level of total protein of the treatment group was higher than that of the control group, but the serum levels of prealbumin and HSV-IgM were lower than those of the control group (P < 0.05). Conclusion Kouqiangyan Spray combined with Ganciclovir Dispersible Tablets can improve the therapeutic effect of herpetic stomatitis, improve clinical symptoms, reduce inflammatory reaction, and improve immune function.

R988.2

江苏省青年医学重点人才培养项目（QNRC2016907）