目的 探讨玉屏风颗粒联合盐酸多西环素片治疗儿童支原体肺炎的临床疗效。方法 选取2023年3月—2024年12月川北医学院附属三台医院收治的82例支原体肺炎患儿，按随机数字表法将82例患儿分为对照组和治疗组，每组41例。对照组口服盐酸多西环素片，每12小时服药1次，每次剂量2.2 mg/kg。治疗组患儿在对照组基础上温水冲服玉屏风颗粒，1袋/次，3次/d。两组持续治疗7 d。比较两组的临床效果、症状消失时间和血清指标。结果 对照组的总有效率为80.49%，治疗组的总有效率为95.12%，组间比较差异显著（P＜0.05）。治疗组患儿发热、咳嗽、肺啰音消失时间均短于对照组（P＜0.05）。治疗后，两组的血清血清淀粉样蛋白A/C反应蛋白（SAA/CRP）、半胱氨酰白三烯（CysLTs）、免疫球蛋白M（IgM）均降低（P＜0.05）；治疗组的血清SAA/CRP、CysLTs、IgM均低于对照组（P＜0.05）。结论 玉屏风颗粒联合盐酸多西环素片可提高儿童支原体肺炎的临床疗效，减轻临床症状和炎症反应。

Objective To explore the clinical efficacy of Yupingfeng Granules combined with Doxycycline Hydrochloride Tablets in treatment of mycoplasma pneumonia in children. Methods 82 Children with mycoplasma pneumonia admitted to Santai Hospital Affiliated to North Sichuan Medical College from March 2023 to December 2024 were divided into control group and treatment group according to random number table method, with 41 cases in each group. Children in the control group took Doxycycline Hydrochloride Tablets orally, once every 12 hours, with a dose of 2.2 mg/kg each time. On the basis of the control group, the treatment group took Yupingfeng Granules orally in warm water, 3 times daily, 1 bag/time. Two groups received continuous treatment for 7 days. The clinical efficacy, symptom disappearance time, and serum indicators were compared between two groups. Results The total effective rate of the control group was 80.49%, and the total effective rate of the treatment group was 95.12%, with significant differences between two groups (P < 0.05). The disappearance times of fever, cough, and lung rales in the treatment group was shorter than those in the control group (P < 0.05). After treatment, the serum levels of SAA/CRP, CysLTs, and IgM in two groups were significantly decreased (P < 0.05), and the serum levels of SAA/CRP, CysLTs, and IgM in the treatment group were lower than those in the control group (P < 0.05). Conclusion The combination of Yupingfeng Granules and Doxycycline Hydrochloride Tablets can improve the clinical efficacy of mycoplasma pneumonia in children, alleviate clinical symptoms and inflammatory reactions.

R974

四川养老与老年健康协同创新中心联合基金项目（YLKYYB2222）