目的 观察槐杞黄颗粒与丙酸氟替卡松雾化吸入联合治疗支气管哮喘患儿的临床疗效。方法 选取2023年1月—2024年6月自贡市妇幼保健院儿科收治的哮喘120例患儿，按照随机数字法分为对照组和治疗组，每组60例。对照组给予丙酸氟替卡松吸入气雾剂，2喷/次，2次/d。治疗组在对照组的基础上口服槐杞黄颗粒，1袋/次，2次/d。两组治疗28 d。对比两组疗效情况，比较两组儿童呼吸困难评分（PRAM）、哮喘控制测试评分（ACT）、白三烯B4（LTB4）、白细胞介素4（IL-4）、肿瘤坏死因子-α（TNF-α）、白细胞介素17（IL-17）、嗜酸性粒细胞趋化因子（Eotaxin）、单核细胞趋化蛋白1（MCP-1）、γ干扰素（IFN-γ）水平。结果 药物治疗后，治疗组总有效率98.33%，高于对照组83.33%（P＜0.05）。治疗28 d后，治疗组喘息、咳嗽、气促、胸闷缓解时间均短于对照组（P＜0.05）。治疗后，两组患儿PRAM评分显著降低，而ACT评分显著升高（P＜0.05）；治疗后，与对照组对比，治疗组PRAM评分较低，ACT评分较高（P＜0.05）。治疗后，两组患儿Eotaxin、MCP-1显著降低，而IFN-γ水平升高（P＜0.05）；治疗后，与对照组对比，治疗组Eotaxin、MCP-1水平均较低，IFN-γ水平较高（P＜0.05）。治疗后，两组LTB4、IL-4、TNF-α、IL-17水平均较治疗前显著降低（P＜0.05）；治疗后，与对照组对比，治疗组患者LTB4、IL-4、TNF-α、IL-17水平均较低（P＜0.05）。结论 槐杞黄颗粒联合丙酸氟替卡松雾化吸入治疗效果明显，有助于改善支气管哮喘患儿的免疫相关因子及炎性因子，且药物安全，值得借鉴与应用。

Objective To investigate the therapeutic effect of Huaiqihuang Granules combined with fluticasone propionate in treatment of asthma. Methods A total of 120 children with admitted to the pediatric department of Zigong Maternal and Child Health from January 2023 to June 2024 were selected and divided (60 cases) according to random number method. Patients in control were given Fluticasone Propionate Inhalation Aerosol, 2 spray/time, twice daily. Patients in the treatment were given Huaiqihuang Granules on the basis of control, 1 bag/time, twice daily. Both were treated for 28 d. The efficacy of two groups was compared, PRAM score, ACT score, LTB4, IL-4, TNF-α, IL-17, Eotaxin, MCP-1, and IFN-γ were compared between two groups. Results After drug treatment, the total effective rate 98.33%, which was significantly higher (83.33%, P < 0.05). After 28 d of treatment, the remission time of wheezing, cough, shortness of breath and chest tightness in the treatment group was shorter than that in the control group (P < 0.05). After treatment, PRAM score was significantly decreased, but ACT score was significantly increased in both groups (P < 0.05). After treatment, compared with control group, PRAM score was lower and ACT score was higher in treatment group (P < 0.05). After treatment, Eotaxin and MCP-1 were significantly decreased, but IFN-γ levels were increased in both groups (P < 0.05). After treatment, compared with control group, Eotaxin and MCP-1 levels in treatment group were lower, IFN-γ levels were higher (P < 0.05). After treatment, the levels of LTB4, IL-4, TNF-α, and IL-17 in both groups were significantly decreased compared with those before treatment (P < 0.05). After treatment, the levels of LTB4, IL-4, TNF-α, and IL-17 in treatment group were lower than those in control group (P < 0.05). Conclusion Huaiqihuang Granules combined with fluticasone propionate has significant therapeutic effects in treatment of childhood bronchial asthma, and is helpful to improve immune-related factors and inflammatory factors in children with bronchial asthma, and the drug is safe, which is worthy of reference and application.

R974

自贡市卫生健康系统科研课题立项项目（2023-31）