目的 探讨神香苏合丸联合替格瑞洛治疗不稳定心绞痛的临床疗效。方法 将康复大学青岛中心医院于2021年6月—2023年6月收治的不稳定心绞痛患者98例，随机分为对照组（49例）和治疗组（49例）。对照组口服替格瑞洛片，首次治疗负荷剂量为180 mg，随后剂量为90 mg/次，2次/d。治疗组在对照组的基础上口服神香苏合丸，0.7 g/次，1次/d。两组患者治疗6个月。观察两组患者临床疗效，比较治疗前后两组血清炎症指标超敏C反应蛋白（hs-CRP）、白细胞介素-17（IL-17）和肿瘤坏死因子-α（TNF-α）水平，及血液高凝状态指标D-二聚体、全血低切黏度和全血高切黏度。结果 治疗后，治疗组的总有效率为93.88%，显著高于对照组的79.59%（P＜0.05）。与治疗前相比，治疗后，两组hs-CRP、IL-17、TNF-α、D-二聚体、全血低切黏度、全血高切黏度水平均明显下降（P＜0.05），且与对照组比较，治疗后治疗组血清炎症和血液高凝状态指标水平降低幅度更大（P＜0.05）。结论 神香苏合丸联合替格瑞洛治疗不稳定心绞痛疗效确切，能有效改善患者炎症反应、血液高凝状态，且安全性较好。

Objective To explore the therapeutic effect of Shenxiang Suhe Pills combined with ticagrelor in treatment of unstable angina. Methods Patients (98 cases) with unstable angina in Qingdao Central Hospital, University of Health and Rehabilitation Sciences from June 2021 to June 2023 were randomly divided into control (49 cases) and treatment (49 cases) group. Patients in the control group were po administered with Ticagrelor Tablets, the first treatment loading dose was 180 mg, and subsequent doses was 90 mg/time, twice daily. Patients in the treatment group were po administered with Shenxiang Suhe Pills on the basis of the control group, 0.7 g/time, once daily. Patients in two groups were treated for 6 months. After treatment, the clinical evaluations were evaluated, and the levels of serum inflammatory markers hs-CRP, IL-17 and TNF-α, and the levels of D-dimer, whole blood low shear viscosity and whole blood high shear viscosity in two groups before and after treatment were compared. Results After treatment, the total effective rate in the treatment group was 93.88%, which was significantly higher than 79.59% in the control group (P < 0.05). Compared with before treatment, the levels of hs-CRP, IL-17, TNF-α, D-dimer, whole blood low-shear viscosity, and whole blood high-shear viscosity decreased significantly in two groups after treatment (P < 0.05). Compared with the control group, the levels of serum inflammation and blood hypercoagulability indicators in the treatment group were decreased more significantly (P < 0.05). Conclusion The combination of Shenxiang Suhe Pills and ticagrelor has a definite therapeutic effect on unstable angina pectoris, which can effectively improve the patient's inflammatory response and blood hypercoagulability with good safety.

R972

山东省重点研发计划项目（2021SFGC0508）