骨质疏松症是一种全身性骨骼疾病，寻找安全有效的新型治疗手段已成为骨质疏松症研究领域的热点之一。槲皮素作为一种多酚类化合物，对骨质疏松症表现出积极的治疗效果，可通过抗氧化作用、调节炎症因子、具有雌激素样作用、促进骨髓间充质干细胞增殖分化、影响破骨细胞分化和相关信号通路、作用于细胞外基质防治骨质疏松症。综述了槲皮素防治骨质疏松症的作用机制研究进展，以推动槲皮素在骨质疏松症治疗领域的应用。

Osteoporosis is a systemic bone disease, and finding safe and effective new treatment methods has become one of the hotspots in the field of osteoporosis research. Quercetin, as a polyphenolic compound, exhibits a positive therapeutic effect on osteoporosis. Quercetin can prevent and treat osteoporosis through antioxidant effects, regulation of inflammatory factors, estrogen like effects, promotion of proliferation and differentiation of bone marrow mesenchymal stem cells, influence of osteoclast differentiation and related signaling pathways, and action on extracellular matrix. This article reviews the research progress on mechanism of quercetin in preventing and treating osteoporosis, in order to promote its application in the field of osteoporosis treatment.

R982

陕西省重点研发计划项目（2022SF-538）；陕西省中医流派学派传承工作室建设项目（陕中医药发[2018]40号）；咸阳市重点研发计划（2021ZDYF-SF-0036）