目的 探讨香砂六君丸联合莫沙必利治疗功能性消化不良的临床疗效。方法 选取2020年11月—2023年12月资阳市精神病医院收治的104例功能性消化不良患者，按随机数字表法分为对照组和治疗组，每组各52例。对照组饭前口服枸橼酸莫沙必利片，1片/次，3次/d。治疗组在对照组基础上口服香砂六君丸，6 g/次，3次/d。两组疗程均为4周。观察两组临床疗效，比较治疗前后两组主症积分、胃排空指标、症状自评量表（SCL-90）、功能性消化不良生存质量量表（FDDQL）评分及血清胃动素（MTL）、生长抑素（SS）、胃泌素（Gas）、降钙素基因相关肽（CGRP）水平。结果 治疗组总有效率96.15%显著高于对照组的84.62%（P＜0.05）。治疗后两组餐后饱胀不适积分、早饱感积分、中上腹烧灼感积分、中上腹痛积分均显著降低（P＜0.05）；治疗后，治疗组主症积分低于对照组（P＜0.05）。治疗后，两组胃窦收缩频率显著增高，而2 h胃残留率显著降低，胃半排空时间都显著缩短（P＜0.05）；治疗后，治疗组胃窦收缩频率高于对照组，2 h胃残留率和胃半排空时间低于对照组（P＜0.05）。治疗后，两组SCL-90评分都显著降低，FDDQL评分都显著增高（P＜0.05）；治疗后，治疗组SCL-90评分低于对照组，FDDQL评分高于对照组（P＜0.05）。治疗后，两组血清MTL水平都显著上升，血清SS、Gas、CGRP水平均降低（P＜0.05）；治疗后，治疗组MTL水平高于对照组，血清SS、Gas、CGRP水平低于对照组（P＜0.05）。结论 香砂六君丸联合莫沙必利治疗功能性消化不良能有效纠正患者胃肠激素失衡，促进胃排空，减轻临床症状，患者心理状态及生活质量可得到进一步改善，值得临床推广应用。

Objective To explore the clinical efficacy of Xiangsha Liujun Pills combined with mosapride in treatment of functional dyspepsia. Methods 104 Patients with functional dyspepsia admitted to Ziyang Psychiatric Hospital from November 2020 to December 2023 were divided into control group and treatment group by random number table method, with 52 cases in each group. Patients in control group were po administered with Mosapride Citrate Tablets, 1 tablet/time, three times daily. Patients in treatment group were po administered with Xiangsha Liujun Pills on the basis of the control group, 6 g/time, 3 times daily. The treatment course of both groups was 4 weeks. The clinical efficacy of two groups was observed, and the scores of major symptoms, gastric emptying index, Symptom self-rating Scale (SCL-90), functional dyspeptic Quality of Life Scale (FDDQL) and serum levels of motilin (MTL), somatostatin (SS), gastrin (Gas) and calcitonin gene-related peptide (CGRP) were compared before and after treatment. Results The total effective rate (96.15%) in treatment group was significantly higher than 84.62% in control group (P < 0.05). After treatment, the scores of fullness and discomfort, the scores of early satiety, the scores of burning sensation in middle and upper abdomen, and the scores of middle and upper abdominal pain were significantly decreased in both groups (P < 0.05). After treatment, the score of major symptoms in treatment group was lower than that in control group (P < 0.05). After treatment, the frequency of gastric antrum contraction was significantly increased, the gastric residual rate at 2 h was significantly decreased, and the gastric half-empty time was significantly shortened in both groups (P < 0.05). After treatment, the frequency of gastric antrum contraction in the treatment group was higher than that in the control group, and the gastric residual rate and half-empty time at 2 h were lower than those in the control group (P < 0.05). After treatment, SCL-90 score was significantly decreased in both groups, but FDDQL score was significantly increased in both groups (P < 0.05). After treatment, the SCL-90 score of the treatment group was lower than that of the control group, but the FDDQL score was higher than that of the control group (P < 0.05). After treatment, serum MTL levels were significantly increased in both groups, but serum SS, Gas and CGRP levels were decreased (P < 0.05). After treatment, the levels of MTL in treatment group were higher than those in control group, but the serum levels of SS, Gas and CGRP were lower than those in control group (P < 0.05). Conclusion The combination of Xiangsha Liujun Pills and Mosapride can effectively correct the imbalance of gastrointestinal hormones in patients with functional dyspepsia, and can promotie gastric emptying, alleviating clinical symptoms, and further improving patients’ psychological state and quality of life, which is worthy of clinical application.

R975

资阳市医学科学课题项目（KY2023086）