目的 基于加权TOPSIS法构建脯氨酸恒格列净药物利用评价（DUE）标准，为临床合理性用药提供科学依据。方法 以脯氨酸恒格列净说明书为基础，结合相关指南和专家共识建立脯氨酸恒格列净DUE标准；并运用加权TOPSIS法对广东医科大学附属医院2023年10月—2024年12月使用了脯氨酸恒格列净的住院患者病例进行DUE，并根据评价结果进行分析与评价。结果 7项指标对应的相对权重分别为20.24%、19.05%、14.76%、15.95%、7.86%、10.48%、11.67%；C_i≥0.8有312例（60.47%），0.6≤C_i＜0.8有148例（28.68%），C_i＜0.6有56例（10.85%）；56例不合理用药主要集中在观察与监测、不良反应、特殊人群、药物相互作用4个方面。结论 加权TOPSIS法能够为临床药师提供有针对性的药学干预措施，本院脯氨酸恒格列净的使用情况整体良好，但仍需针对存在的问题加强监管，以优化临床用药实践。

Objective Based on the weighted TOPSIS method, the drug utilization evaluation (DUE) criteria of henagliflozin proline was established to provide scientific basis for clinical rational drug use. Methods The DUE of henagliflozin proline were established through a combination of its instructions, pertinent guidelines, and expert consensuses. The weighted TOPSIS method was utilized to assess the DUE of hospitalized patients who were prescribed henagliflozin proline at Guangdong Medical University Affiliated Hospital between October 2023 and December 2024. Subsequently, the findings were subjected to analysis and evaluation. Results Relative weights of the seven indicators were as follows: 20.24%, 19.05%, 14.76%, 15.95%, 7.86%, 10.48%, and 11.67%, respectively. Among the 312 cases with C_i≥0.8 (60.47%), there were 148 cases (28.68%) with 0.6≤C_i＜0.8, and 56 cases (10.85%) with C_i＜0.6. The primary areas of irrational drug use identified were observation and monitoring, adverse reaction, special populations and drug interactions. Conclusion Weighted TOPSIS method can offer precise pharmaceutical interventions for clinical pharmacists. While the overall utilization of henagliflozin proline in our hospital is satisfactory, there is a need to enhance monitoring of current issues to enhance the optimization of clinical medication practices.

R977

广东省基础与应用基础研究基金课题（2023A1515110955）；广东省医学会临床科研专项基金项目（2024HY-A1002）；北京医学奖励基金课题（YXJL-2023-0314-0210）