目的 探讨在尼可地尔片基础上联合瓜蒌皮注射液治疗稳定型心绞痛的临床效果。方法 选择2023年1月—2023年12月在江南大学附属医院就诊的84例稳定型心绞痛患者，经随机数字表法将所有患者分为对照组和治疗组，每组42例。对照组口服尼可地尔片，1片/次，3次/d。在此基础上，治疗组静脉注射瓜蒌皮注射液，12 mL/次，1次/d，注射前用25%葡萄糖注射液250 mL稀释。两组患者治疗1周。比较两组患者治疗效果、心绞痛发作情况、心功能指标、血清心肌谱酶指标、血清脂蛋白相关磷脂酶A2（Lp-PLA2）水平和血清炎症因子。结果 治疗组的总有效率（95.24%）显著高于对照组总有效率（80.95%，P＜0.05）。治疗后，两组心绞痛发作次数和发作时间均降低（P＜0.05），治疗组心绞痛发作次数和发作时间低于对照组（P＜0.05）。治疗后，两组左心室射血分数（LVEF）升高，左心室舒张末期内径（LVEDD）降低（P＜0.05）；治疗组LVEF高于对照组，LVEDD低于对照组（P＜0.05）。治疗后，两组血清N末端B型利钠钛前体（NT-proBNP）、Lp-PLA2、C反应蛋白（CRP）、白细胞介素-6（IL-6）水平显著降低（P＜0.05）；治疗组血清NT-proBNP、Lp-PLA2、CRP、IL-6水平低于对照组（P＜0.05）。结论 稳定型心绞痛患者经瓜蒌皮注射液和尼可地尔片联合治疗可以提高治疗效果，有效缓解患者的心绞痛发作情况，改善心功能指标和心肌谱酶指标，调节血清Lp-PLA2水平，降低炎症反应。

Objective To explore the clinical effect of Gualoupi Injection combined with Nicorandil Tablets in treatment of stable angina pectoris. Methods84 Patients with stable angina pectoris in Affiliated Hospital of Jiangnan University from January 2023 to December 2023 were divided into control group and treatment group using a random number table method, with 42 patients in each group. Patients in the control group took Nicorandil Tablets orally, 1 tablets/time, 3 times daily. On this basis, patients in the treatment group were iv administered with Gualoupi Injection, 12 mL/time, once daily, diluted with 250 mL 25% glucose injection. All patients were treated for one week. The treatment effect, angina pectoris attack, cardiac function indexes, serum myocardial spectrum enzyme index, serum lipoprotein-associated phospholipase A2 (Lp-PLA2) level, and serum inflammatory factors were compared between the two groups. Results The total effective rate (95.24%) of the treatment group was significantly higher than 80.95% of the control group (P < 0.05). The frequency and duration of angina attacks in both groups were decreased after treatment (P < 0.05), and the frequency and duration of angina attacks in treatment group was lower than those in the control group (P < 0.05). After treatment, LVEF in both groups was increased, but LVEDD was decreased (P < 0.05). After treatment, LVEF of the treatment group was higher than those in the control group, but LVEDD was lower than those in the control group (P< 0.05). After treatment, the levels of NT-proBNP, Lp-PLA2, CRP, and IL-6 in two groups were significantly decreased (P < 0.05), and compared with control group, the levels of serum indexes in the treatment group were lower (P< 0.05). Conclusion Gualoupi Injection combined with Nicorandil Tablets in treatment of stable angina pectoris can improve treatment efficacy, effectively alleviate angina attacks, improve cardiac function indicators and myocardial spectrum enzyme indicators, regulate serum Lp-PLA2 levels, and reduce inflammatory reactions.

R972

无锡市卫健委科研项目（M202222）