目的 评价抑制胃酸分泌药的药物相互作用（DDI）。方法 在MCDEX数据库药物相互作用版块中检索抑制胃酸分泌药的DDI，并对其进行归纳分析。结果 28种抑制胃酸分泌药在MCDEX数据库中提示存在3 607对DDI，其中禁忌合用、不推荐合用、谨慎合用、关注、可以合用的分别有50、168、2 214、979、196对。H₂受体阻滞剂类抑酸药DDI最多，其中西咪替丁的DDI达777对。结论 抑制胃酸分泌药物较易与其他药物发生相互作用，主管医师和临床药师应对其药物治疗方案进行整理和优化，避免因DDI引起药物不良反应或导致疗效降低。

Objective To evaluate and analyze the drug-drug interactions（DDI） of anti-gastric acid secretion drugs. Methods The DDI of anti-gastric acid secretion drugs in MCDEX databases’ drug interaction section were selected, the results were analyze and summarized. Results 3 607 Pairs of DDIs were identifined in MCDEX databases involving 28 types of anti-gastric acid secretion drugs, the DDIs that were taboo combination use, not recommended combination use, cautious combination use, pay attention to use, can be used in combination were 50, 168, 2 214, 979, and 196, respectively. The quantities of DDIs in H₂ receptor antagonists was the most. Among them, the DDI of cimetidine reached 777 pairs. Conclusion The anti-gastric acid secretion drugs are more likely to interact with others, chief physician and clinical pharmacists should pay more attention on these patients to avoid the adversr drug reactions during therapy.

R974

中国药学会科技开发中心项目(CMEI2024KPYJ00606;CMEI2024KPYJ00809)