目的 探讨云南白药胶囊联合艾普拉唑钠治疗消化性溃疡出血的临床疗效。方法 选取2022年5月—2024年4月聊城市第二人民医院收治的162例消化性溃疡出血患者，按随机数字表法将患者分为对照组和治疗组，每组各81例。对照组静脉滴注给予注射用艾普拉唑钠，与0.9%氯化钠溶液按10 mg∶100 mL的比例混合，首次20 mg/次，后续10 mg/次，1次/d。治疗组对照组治疗基础上口服云南白药胶囊，2粒/次，3次/d。两组连续治疗7 d。观察两组临床疗效、症状缓解时间和禁食时间。比较两组治疗前后症状自评量表（SCL-90）评分、简式抑郁–焦虑–压力量表（DASS-21）评分、格拉斯哥–布拉奇福德出血评分（GBS）评分、血常规相关指标[血红蛋白（Hb）、红细胞计数（RBC）、血细胞比容（HCT）]及血清C反应蛋白（CRP）水平。结果 治疗后，治疗组总有效率是97.53%，显著高于对照组的88.89%(P<0.05)。治疗后，治疗组腹痛、黑便、呕血、心慌、乏力缓解时间和禁食时间均短于对照组（P<0.05）。治疗后，两组SCL-90、DASS-21、GBS评分均显著低于治疗前（P<0.05）；治疗后，治疗组SCL-90、DASS-21、GBS评分低于对照组（P<0.05）。治疗后，两组Hb、RBC、HCT都高于治疗前，而血清CRP水平均显著下降（P<0.05）；治疗后，治疗组血常规相关指标和血清CRP水平改善优于对照组（P<0.05）。结论 云南白药胶囊联合艾普拉唑钠治疗消化性溃疡出血具有较好临床疗效，能有效缓解消化道溃疡出血及伴随症状，减轻患者病情严重程度及不良情绪，值得临床推广应用。

Objective To explore the clinical efficacy of Yunnan Baiyao Capsules combined with eprazole sodium in treatment of peptic ulcer bleeding. Methods A total of 162 patients with peptic ulcer bleeding admitted to The Second People’s Hospital of Liaocheng from May 2022 to April 2024 were selected and divided into control group and treatment group according to random number table method, with 81 patients in each group. Patients in control group were iv administered with Eprazole Sodium for injection, mixed with 0.9% sodium chloride solution at the ratio of 10 mg to 100 mL, 20 mg/time for the first time, 10 mg/time for the subsequent time,once daily. Patients in treatment group were po administered with Yunnan Baiyao Capsules on the basis of the control group, 2grains/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy, symptom relief time,and fasting time of two groups was evaluated. Symptom Rating Scale（SCL-90）, simplified depression-Anxiety-Stress Scale（DASS-21）, Glasgow-Blatchford hemorrhage score（GBS）, blood routine related indicators [hemoglobin（Hb）, red blood cell count（RBC）, hematocrit（HCT）] and serum C-reactive protein were compared between two groups before and after treatment. Results After treatment, the total effective rate of treatment group was 97.53%, which was significantly higher than that of control group（88.89%, P＜0.05）. After treatment, the relief time of abdominal pain, black stool, hematemesis, palpitation, fatigue and fasting time in treatment group were shorter than those in control group（P＜0.05）. After treatment, SCL-90, DASS-21, and GBS scores in two groups were significantly lower than before treatment（P＜0.05）. After treatment, the scores of SCL-90, DASS-21, and GBS in treatment group were lower than those in the control group（P＜0.05）. After treatment, Hb, RBC, and HCT in both groups were higher than before treatment, but serum CRP levels were significantly decreased（P＜0.05）. After treatment, the improvement of blood routine related indexes and serum CRP level in treatment group was better than that in control group（P＜0.05）. Conclusion Yunnan Baiyao Capsules combined with eprazole sodium has a good clinical effect in treatment of peptic ulcer bleeding, and can effectively relieve gastrointestinal ulcer bleeding and accompanying symptoms, reduce the severity of patients’ disease and bad mood, which is worthy of clinical application.

R975

山东省医学会临床科研资金项目(YXH2022ZX02072)