抑郁症是常见的精神疾病之一，发病机制复杂，目前尚缺乏有效的根治药物。黄芩苷是一种来自黄芩的天然黄酮类成分，具有多种药理作用，可通过促进神经发生、增强神经突触可塑性、调节丘脑–垂体–肾上腺（HPA）轴、减轻神经炎症反应、抑制神经元细胞凋亡、改善线粒体功能发挥抗抑郁作用。总结了黄芩苷抗抑郁作用的研究进展，分析其作用机制，为黄芩苷的临床应用提供循证支持。

Depression is a common mental disorder with complex pathogenesis, and there is currently a lack of effective cure drugs. Baicalin is a natural flavonoid extracted from Scutellariae Radix, which has various pharmacological effects. Baicalin can exert antidepressant effects by promoting neurogenesis, enhancing synaptic plasticity, regulating the HPA axis, reducing neuroinflammatory responses, inhibiting neuronal cell apoptosis, and improving mitochondrial function. This paper summarized the research progress on the antidepressant effect of baicalin, analyzed its mechanism of action, and provided evidence-based support for the clinical application of baicalin.

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